肢体骨肉瘤的新辅助化疗：异环磷酰胺、甲氨蝶呤、表柔吡星化疗的初步结果

目的评价新辅助化疗的疗效和在骨肉瘤保肢手术方面的作用。方法2001年9月～2005年4月治疗53例肢体骨肉瘤患者。化疗方案：异环磷酰胺2．0g／m^2，第1～5天；甲氨蝶呤8g／m^2，第3天；表柔吡星60mg／m^2，第5天。每3～4周重复1次。评价化疗反应和化疗毒性。术前化疗3次，术后化疗6次。结果2例患者死于化疗毒性反应。完全缓解（CR）23例，部分缓解（PR）15例、稳定（SD）9例、进展（PD）5例。44例患者进行保肢手术，8例进行截肢。3年生存率为77．36％。结论异环磷酰胺、甲氨蝶呤、表柔吡星联合化疗方案有利于保肢手术，改善患者的预后，可以作为一种较理想的化疗方案。

Neoadjuvant chemotherapy for osteosarcoma:three-year results of ifosfamide,methotrexate and epirubicin

Objective To retrospectively evaluate the efficacy and role of neoadjuvant chemotherapy for osteosarcoma with ifosfamide,methotrexate and epirubicin in limb salvage surgery.Methods Fifty-three patients with osteosarcoma were consecutively treated from September,2001 to April,2005 with neoadjuvant chemotherapy based on ifosfamide 2.0g/m2/day on days 1 to 5,methotrexate 8g/m2/day on day 3 and epirubicin 60mg/m2 on day 5.Repeated again every three to four weeks.Three times of chemotherapy and six times of chem...