血管性痴呆的危险因素探讨

目的　探讨血管性痴呆(vasculardementia ,VD)可能的危险因素。方法　临床诊断为很可能VD患者111例,性别、职业和受教育程度相匹配的认知功能正常老年人15 5例为对照,以logistic回归模型分析各种危险因素如高血压、糖尿病、冠心病、短暂性脑缺血发作等与VD的关系。结果　单因素分析显示,高血压、糖尿病、冠心病、心脏传导阻滞、短暂性脑缺血发作、慢性阻塞性肺疾病、高脂血症、贫血病史以及年龄与VD有关;多因素分析证实贫血、高血压、糖尿病、短暂性脑缺血发作和冠心病与VD有关,OR值(95 %CI)依次为5 .15 (2 .31～11.4 8) ,4 .11(2 .0 3～8.32 ) ,2 .15 (1.17～3.94 ) ,2 .0 8(1.12～3.86 ) ,2 .0 4 (1.0 7～3.87)。结论　贫血、高血压、糖尿病、短暂性脑缺血发作和冠心病与VD有关,可能是VD的独立危险因素。

The risk factors of vascular dementia

Objective To explore the possible risk factors of vascular dementia(VD).Methods A case-control study included 155 cognitive normal controls and 111 probable VD in Chinese PLA General Hospital. The cases and controls were matched for gender,occupation and the education level. The relationship between VD and various factors such as hypertension,diabetes mellitus,coronary heart diseases and transient ischemic attack(TIA) was analysed by logistic model.Results Univariate analysis showed that 9 factors were found to be correlated with VD including hypertension , diabetes mellitus, coronary heart diseases, heart block, TIA, chronic obstructive pulmonary diseases, hyperlipidemia, anaemia and age. Multivariate analysis confirmed that the history of anaemia, hypertension, diabetes mellitus, TIA and coronary heart diseases was related to VD. The OR (95% confidence interval,95%CI) was 5.15(2.31～11.48),4.11(2.03～8.32),2.15(1.17～ 3.94), 2.08(1.12～3.86),2.04(1.07～3.87)in turn.Conclusion VD is associated with the history of anaemia, hypertension, diabetes mellitus, TIA and coronary heart diseases, and they may be the independent risk factors of VD.