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| 嵌合抗原受体-T细胞免疫治疗在黑素瘤中的应用进展 | |
| 引用本文： | 邓心怡,顾建英. 嵌合抗原受体-T细胞免疫治疗在黑素瘤中的应用进展[J]. 中国临床医学, 2019, 26(6): 942-945 |
| 作者姓名： | 邓心怡 顾建英 |
| 作者单位： | 复旦大学附属中山医院整形外科, 上海 200032,复旦大学附属中山医院整形外科, 上海 200032 |
| 基金项目： | 复旦大学附属中山医院院内科研课题（2017YFC0910003）. |
| 摘 要： | 嵌合抗原受体(chimeric antigen receptor,CAR)-T细胞疗法是一种过继性细胞免疫疗法,近年来在肿瘤免疫治疗中极具研究前景。目前,CAR-T细胞疗法已运用于血液系统恶性肿瘤(如急性B淋巴细胞白血病等)的研究和临床治疗中,并取得了不俗成果。但对于将CAR-T细胞运用于实体肿瘤的治疗仍存在相当多的困难。本文就CAR-T细胞疗法的原理、在黑素瘤治疗中的应用及面临的挑战、CAR-T细胞治疗的副作用和相应对策等方面进行综述。 |
| 关 键 词： | 嵌合抗原受体 T淋巴细胞 黑素瘤 肿瘤免疫治疗 |
| 收稿时间： | 2019-05-13 |
| 修稿时间： | 2019-10-08 |
The progress of chimeric antigen receptor-T cell immunotherapy in the treatment of melanoma |
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| DENG Xin-yi and GU Jian-ying. The progress of chimeric antigen receptor-T cell immunotherapy in the treatment of melanoma[J]. Chinese Journal Of Clinical Medicine, 2019, 26(6): 942-945 | |
| Authors: | DENG Xin-yi and GU Jian-ying |
| Affiliation: | Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China and Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China |
| Abstract: | The application of chimeric antigen receptor-T cell (CAR-T) cells is a promising cellular immunotherapy in oncotherapy recent years. Gratifying results have been achieved in the treatment of hematologic malignancies such as B-lymphocytic leukemia by using CAR-T cells, but considerable difficulties still need to be overcome in the treatment of solid tumors. This review mainly discusses the principle, application, as well as the side effects of CAR-T cells therapy. |
| Keywords: | Chimeric antigen reporter T cell melanoma tumor immunotherapy |
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