非小细胞肺癌骨转移的预后因素分析

目的：探讨非小细胞肺癌（ NSCLC）骨转移患者骨相关事件（ SREs）的发生，并分析患者的预后因素。方法回顾性分析我科诊治的118例NSCLC骨转移患者SREs的发生率，并分析各预后相关危险因素，单因素分析应用Kaplan-Meier法，多因素分析应用Cox回归模型。结果118例患者中，44例（37.3%）在初诊为骨转移时即发生SREs，118例患者中位生存时间为13（11.11~14.89）个月，单因素分析显示，病理类型、骨转移灶数目、PS评分、诊断骨转移时是否发生SREs、是否给予靶向治疗与预后有关；而多因素分析则显示病理类型、骨转移灶数目、PS评分、是否给予靶向治疗是影响预后的独立因素。结论在发生SREs的NSCLC骨转移患者中，对腺癌、单发骨转移灶、PS评分为0~1分的患者给予更积极的治疗，有可能使这部分患者生存受益。

Prognostic Factors for Non-small-cell Lung Cancer with Bone Metastasis

Objective To investigate the skeletal related events （SREs） and the prognostic factors of non-small- cell lung cancer （NSCLC） patients with bone metastasis. Methods One hundred and eighth NSCLC patients with SREs were investigated retrospectively. The frequency of SREs and the prognostic factors were analyzed. Results Of the 118 patients, 44 experienced SREs at the initial diagnosis of NSCLC with bone metastasis. The median sur- vival time was 13（11.11-14.89） months for the 118 patients. The univariate analysis showed that the significant prognostic factors included tumor subtype, number of skeletal metastases, PS score, SREs at the initial diagnosis of NSCLC with bone metastasis and target therapy. The multivariate analysis indicated that tumor subtype, number of skeletal metastases, PS score and target therapy were independent prognostic factors. Conclusion For the NSCLC patients with bone metastasis, the patients with adenocarcinoma, single bone metastasis, good PS score are treated more positively, their mean survival may be longer.