| MAGE-12 mRNA在肺癌中的表达及其意义 |
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| 引用本文： | 李艳秋,吴玉章,倪兵,贾正才. MAGE-12 mRNA在肺癌中的表达及其意义[J]. 第三军医大学学报, 2002, 24(10): 1146-1148 |
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| 作者姓名： | 李艳秋 吴玉章 倪兵 贾正才 |
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| 作者单位： | 沈阳军区总医院检验科,沈阳,110015;第三军医大学基础医学部全军免疫学研究所,重庆,400038 |
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| 基金项目： | 国家重点基础研究发展规划资助项目 (“973”项目 ) ( 2 0 0 1CB510 0 0 1) |
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| 摘 要： | 目的 探讨肺癌组织中MAGE 12mRNA的表达及其意义。方法 采用RT PCR技术 ,检测了MAGE 12在 5 0例临床病人肺癌标本中mRNA水平的表达。结果 5 0例临床肺癌标本中有 17例表达 (17 5 0 ,3 4% ) ,且肺鳞癌 (15 3 3 ,45 5 % )与肺腺癌 (2 17,11 8% )有显著差异 (P <0 0 5 )。结论 MAGE 12基因在肺癌有较高的表达率 ,基于MAGE 12基因及其产物作为新的疫苗可能是一个有前途的治疗肺癌的免疫治疗方法
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| 关 键 词： | 肿瘤抗原 MAGE-12 肺癌 RT-PCR |
| 文章编号： | 1000-5404(2002)10-1146-03 |
| 修稿时间： | 2002-02-05 |
Expression of tumor antigen MAGE-12 mRNA in lung cancer and its significance |
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| LI Yan-qiu,WU Yu-zhang,NI Bing,JIA Zheng cai. Expression of tumor antigen MAGE-12 mRNA in lung cancer and its significance[J]. Acta Academiae Medicinae Militaris Tertiae, 2002, 24(10): 1146-1148 |
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| Authors: | LI Yan-qiu WU Yu-zhang NI Bing JIA Zheng cai |
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| Abstract: | Objective To investigate the expression of MAGE 12 mRNA in lung cancer and its relationship with pathological types Methods The expression of MAGE 12 gene was detected in samples of 50 cases of clinical lung cancer with RT PCR The results were analyzed with their pathological types Results MAGE 12 expression was found in 17 samples (34%), and the positive rate was significantly different in squamous cell carcinomas (45 5%,15/33) and in adenocarcinoma (11 8%,2/17) Conclusion MAGE 12 mRNA is expressed in lung cancer in a high level, implying tumor vaccines based on MAGE 12 or its product may be contributive in the treatment of lung cancer |
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| Keywords: | tumor antigen lung cancer MAGE 12 RT PCR |
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