| 上海地区汉族人解偶联蛋白3基因的变异 |
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| 引用本文： | 张蓉,郑以漫,项坤三,贾伟平,方启晨. 上海地区汉族人解偶联蛋白3基因的变异[J]. 上海交通大学学报(医学版), 2001, 21(1) |
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| 作者姓名： | 张蓉 郑以漫 项坤三 贾伟平 方启晨 |
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| 作者单位： | 上海第二医科大学市六临床医学院内分泌科, |
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| 摘 要： | 目的探讨解偶联蛋白P3(UCP3)基因Ⅳ6G→a+1变异与中国汉族人肥胖及糖尿病的关系。方法选取306例无亲缘关系的中国人和66例白种人，运用PCR-RFLP方法检测UCP3基因Ⅳ两Pa+1的变异情况。结果中国人与白种人中均未发现这种变异。结论该基因变异不是中国汉族人肥胖与糖尿病发生的重要遗传因素。
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| 关 键 词： | 解偶联蛋白3基因 变异 肥胖 |
A Study on the Variance of Uncoupling Protein 3 Gene in Shanghai Han Race |
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| Abstract: | Objective To investigatce the relationship between ⅣS6 g→a + 1 variance of un-coupling protein 3 gene (UCP3) and obesity as well as diabetes in Chinese Hans. Methods The geno-type of this variance was determined by the PCR-RFLP method in 306 unrelated Shanghai ChineseHans and 66 normal Caucasians. Results No ⅣS6 g→a + 1 variance of UCP3 gene was found in thisgroup of Shanghai Chinese Hans and 66 Caucasians. Conclusion This variance of UCP3 gene is not amajor predisposing genetic factor for obesity and diabetes in Chinese Hans. |
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