血塞通注射液与贝那普利联合治疗糖尿病肾病42例疗效观察

目的观察血塞通注射液与贝那普利（洛丁新）联合治疗糖尿病肾病（DN）的临床疗效。方法将80例DN患者随机分为治疗组（42例）和对照组（38例），两组均予常规降糖治疗，贝那普利口服每次10mg，每日1次。治疗组予血塞通注射液210mg加入生理盐水250ml静脉滴注，每日1次，15d为1个疗程，停用5d后开始第2疗程，共2个疗程。结果两组SBP、DBP、FBG、PBG、24h尿蛋白定量、SCr、BUN、ALB、血液流变学、CHOL、TG治疗后与治疗前比较差异有统计学意义（P〈0．05）；治疗组治疗后24h尿蛋白定量、SCr、BUN、ALB、血液流变学与对照组治疗后比较差异有统计学意义（P〈0．05）。结论血塞通注射液与贝那普利联合应用治疗DN，在减少尿蛋白，改善肾功能方面明显优于单用贝那普利组，提示两药合用在延缓DN进展方面能够发挥各自的优势，起到协同作用。

Xuesetong injection and beinazepril in treating diabetic nephropathy

Objective To observe the clinical effect of combination Xuesetong injection and beinazepril in treating patients with diabetic nephropathy(DN).Methods Eighty patients of DN were randomly divided into the treating group(42 cases) and the control group(38 cases).Conventional treatment was given to both groups,the control group was treated with 10mg beinazepril every day.The treating group was treated with the same quantity of beinazepril,210mg Xuesetong injection and 0.9% NS 250ml daily for 15d.5d later began the second course.All the patients of the treating group were treated with 2 courses.Results SBP,DBP,the quantity of urinary albumin in 24h,FBG,PBG,Scr,BUN,ALB,hemorrheology,CHOL,TG had no significant difference between pretherapy and post-therapy in two groups(P<0.05).After 2 courses of treatment,significant difference was found in the quantity of urinary albumin in 24h,Scr,BUN,ALB,hemorrheology between control group and treateing group(P<0.05).Conclusion Combination of Xuesetong injection and beinazepril on DN is better than beinazepril in reducing the albuminuria and improving renal function.