| SLE患者淋巴细胞膜上IL-2R表达的动态分析 |
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| 引用本文： | 谢平,殷志伟.SLE患者淋巴细胞膜上IL-2R表达的动态分析[J].现代免疫学,1993,13(3):143-145. |
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| 作者姓名： | 谢平 殷志伟 |
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| 作者单位： | 苏州医学院病理生理学教研室，苏州医学院病理生理学教研室，苏州医学院病理生理学教研室，苏州医学院病理生理学教研室，苏州医学院病理生理学教研室 苏州 215007，苏州 215007，苏州 215007，苏州 215007，苏州 215007 |
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| 基金项目： | 江苏省科学技术委员会资助 |
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| 摘 要： | 本实验采用Wu Tac单克隆抗体的间接荧光抗体法,动态观察了系统性红斑狼疮(SLE)患者和正常供血员(对照组)的外周血淋巴细胞经PHA刺激后,于不同时间(0、24、48、72小时)内细胞膜上白细胞介素2受体(IL-2R)的表达。结果表明在给予PHA刺激培养24、48和72小时后,与对照组比较SLE患者淋巴细胞的IL-2R表达明显下降,提示了SLE的T淋巴细胞反应性降低可能与被激活的T细胞表面IL-2R的表达功能缺陷有关。此结果将有助于进一步探讨SLE的免疫调节紊乱的发生机制。
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| 关 键 词： | 系统性红斑狼疮 白细胞介素2受体 淋巴细胞 |
A DYNAMIC OBSERVATION OF THE EXPRESSION OF IL-2R ON LYMPHOCYTES FROM SLE PATIENTS |
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| Xie Ping Yin Ziwei Hu Yumin Luo Jianjun Mao Zijun.A DYNAMIC OBSERVATION OF THE EXPRESSION OF IL-2R ON LYMPHOCYTES FROM SLE PATIENTS[J].Current Immunology,1993,13(3):143-145. |
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| Authors: | Xie Ping Yin Ziwei Hu Yumin Luo Jianjun Mao Zijun |
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| Institution: | Xie Ping Yin Ziwei Hu Yumin Luo Jianjun Mao Zijun Department of Pathophysiology,Suzhou Medical College,Suzhou |
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| Abstract: | With indirect fluorescent antibody techniques (IFAT), we studied the expression of IL-2E on lymphocytes from SLE patients. These lymphocytes were stimulated by PHA and cultivated 0, 24, 48 and 72 hours. Compared with those in controls, we found that the expressions of IL-2R on lymphocytes cultivated 24,48 and 72 hours in SLE patients obviously decreased. Our results may contribute to the study on the immunoregulatory aberration of SLE. |
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| Keywords: | SLE IL-2R lymphocyte |
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