The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection. |
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| Authors: | Li Shen Lisheng Zhuo Akihiko Okumura Tetsuya Ishikawa Masahiko Miyachi Yoshihiro Owa Tohko Ishizawa Nobuo Sugiura Yoshihisa Nagata Toshiaki Nonami Shinichi Kakumu Koji Kimata |
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| Affiliation: | Institute for Molecular Science of Medicine, Aichi Medical University, Yazako, Nagakute, Aichi 480-1195, Japan; Department of Surgery, Aichi Medical University, Yazako, Nagakute, Aichi 480-1195, Japan. |
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| Abstract: | ![]()
Our previous study suggested that the serum-derived hyaluronan associated protein (SHAP)-hyaluronan (HA) complex in the sera of patients with rheumatoid arthritis is useful as a marker that directly correlates with the degree of inflammation. Here, we have investigated the serum levels of the SHAP-HA complex in patients at various clinical stages of chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) caused by infection with the hepatitis C or hepatitis B virus. Both serum levels of the SHAP-HA complex and HA in those patients were significantly higher than those of the controls and increased in the order of CH
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| Keywords: | SHAP, serum-derived hyaluronan associated protein HA, hyaluronan CH, chronic hepatitis LC, liver cirrhosis HCC, hepatocellular carcinoma TSG-6, tumor necrosis factor-stimulated gene-6 HCV, hepatitis C virus HBV, hepatitis B virus B-CH, HBV-induced CH B-LC, HBV-induced LC B-HCC, HBV-induced HCC C-LC, HCV-induced LC C-CH, HCV-induced CH C-HCC, HCV-induced HCC ITI, inter-α-trypsin inhibitor HRP, horseradish peroxidase BSA, bovine serum albumin Alb, albumin ALT, alanine aminotransferase AFP, α-fetoprotein Plt, platelet count |
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