老年慢性肝病患者乙型和丙型肝炎病毒重叠感染的研究

对213例老年慢性肝病患者的HBV和HCV血清标志物检测发现:HBV感染占73.24％、HBV和HCV重叠感染占15.49％、HCV感染占7.04％、其它占4.23％;HBV阴性者HCV检出率高于HBV阳性者,肝癌和肝硬化患者较慢性肝炎患者高（P<0.01）;HBV和HCV重叠感染患者的血清白蛋白下降显著,r—球蛋白升高明显,肝硬化并腹水和上消化道出血者多（P<0.01或<0.05）。结果表明,老年慢性肝病患者以HBV感染为主,其次是HBV和HCV重叠感染。重叠感染患者病情重、并发症多、预后差。

A Study of Hepatitis B Virus and Hepatitis C Virus Double-Infection in the Elderly with Chronic Liver Disease

Hepatitis B virum(HBV) and hepatitis C virum(HCV) serai markers were determined in 213 elderly patients with chronic liver disease. The prevalence ofHBV infection was 73.24%,HBV and HCV double-infection was 15.49% ,HCV infection was 7. 04% and others was 4. 23%. The detective rate of anti-HCV in the patients with HBV markers negatine were higher than in positive and higher the patients with hepatoma and iiver cirrhosis than in chronic hepatitis(P<0. 01). In the HBV and HCV superinfection patients, serum albumin level was reduced and gamma glabulin was elevated. In cirrhosis patiohts with ascites and upper gastrointestinal bleeding, there were more double-infection. These findings indicate that in elderly patients,the major infection was HBV,followed by HBV and HCV superinfection. For double-infection,the condition was serious and the prognosis was bad.