正交试验优选复方水杨酸氯霉素凝胶基质

目的:优选复方水杨酸氯霉素凝胶基质的最佳配比。方法:以羧甲基纤维素钠、甘油、乙醇用量为考察对象,以综合评分为指标,采用L9(33)正交试验法优选基质处方,高效液相色谱法测定凝胶中水杨酸和氯霉素的含量。结果:处方中基质的最佳配比为羧甲基纤维素钠3g、甘油10g、乙醇35mL。水杨酸和氯霉素的平均加样回收率分别为99.1%和101.6%,RSD分别为0.8%和1.3%。结论:本法优选出的基质稳定,可为工业化生产提供理论依据。

Optimization of Basic Formula of Compound Salicylic Acid and Chloramphenicol Gel with Orthogonal Test

OBJECTIVE： To optimize the basic formula of Compound Salicylic Acid and Chloramphenicol Gel with orthogonal design test.METHODS： The closage of CMC-Na,glycerin and ethanol were taken as the review obiect with the oligation grade as the evaluation index to conduct L9（3^3） orthogonal test and the contents of salicyclic acid and the chloramphenicol were determined by HPLC. RESULTS： The optimized basic formula was as follows： sodium carboxymethylcellulose 3 g, glycerine 10 g, and alcohol 35 mL.The average recovery of Salicylic Acid and Chloramphenicol were 99.1% and 101.6%, the RSD were 0.8% and 1.3% . CONCLUSION： The basic formula optimized with orthogonal test is proved to be stable and serve as theoretic basis for the industrialized production of this preparation.