| 依达拉奉治疗大鼠脊髓损伤的实验研究 |
| |
| 引用本文： | 吴华,陈继革. 依达拉奉治疗大鼠脊髓损伤的实验研究[J]. 神经损伤与功能重建, 2006, 1(2): 101-102 |
| |
| 作者姓名： | 吴华 陈继革 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院骨外科,武汉,430030;华中科技大学同济医学院附属同济医院创伤外科,武汉,430030 |
| |
| 摘 要： | 目的:探讨依达拉奉(必存)对大鼠脊髓损伤细胞的保护作用。方法:采用Allen法将32只SD大鼠制成脊髓中度损伤模型,随机分为必存组和对照组各16只,分别给予必存及生理盐水治疗,比较治疗前及治疗后6周2组大鼠斜板最大角度和神经功能恢复率。结果:从伤后第2和3周起,必存组斜板最大角度和神经功能恢复率均较对照组明显提高(P<0.01)。结论:必存对大鼠脊髓损伤细胞具有保护作用。
|
| 关 键 词： | 依达拉奉 脊髓损伤 大鼠 |
| 文章编号： | 1001-2001（2006）02-0101-02 |
| 收稿时间： | 2006-04-11 |
| 修稿时间： | 2006-04-11 |
Protective Effect of Edaravone on Rats with Acute Spinal Cord Injury |
| |
| Wu Hua,Chen Ji-ge. Protective Effect of Edaravone on Rats with Acute Spinal Cord Injury[J]. Neural Injury and Functional Reconstruction, 2006, 1(2): 101-102 |
| |
| Authors: | Wu Hua Chen Ji-ge |
| |
| Affiliation: | Department of Or thopedic Surgery, The Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Sience and Technology , Wuhan 430030, China |
| |
| Abstract: | Objective: To observe the effect of edaravone injection on nerve function before and after treatment in rats with acute spinal cord injury and to investigate its protective effect. Methods: Thirty-two rats were enrolled to establish moderate spinal cord injury models using Allen method, and then the rats were randomly divided into treated-group, in which edaravone was injected, and control-group, in which normal saline was injected. Tarlov scale and inclined plane test were conducted on the two groups at 1, 2, 3, 4 and 6 weeks after injury. Results: From the second and third week, both Tarlov scale and inclined plane test revealed significant differences (P<0. 0l ) between the treated group and control group.Conclusions: Edaravone injection showed a protective effect on spinal cells in rats with acute spinal cord injury. |
| |
| Keywords: | edaravone spinal cord injury rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
