227例抗菌药物致药品不良反应报告分析

目的：了解我院抗菌药物致药品不良反应（ADR）发生的特点，促进临床抗菌药物合理使用。方法：对我院2008年1月-2011年1月227例抗菌药物致ADR报告进行回顾性分析。结果：227例抗菌药物致ADR报告中，男性多于女性；60岁以上患者所占比例最高（40．53％）；以喹诺酮类最多（42．29％），其次为-内酰胺类（24．67％）；累及器官／系统以皮肤及其附件损害居多（38．77％），其次为消化系统损害（25．55％）。结论：医院应重视抗茵药物使用管理，加强ADR监测。

The Analysis of 227 Adverse Drug Reaction Reports Caused by Antibacterials in Our Hospital

Objective：To investigate the features of the adverse drug reactions （ADRs） caused by antibacterials in our hospital so as to improve the rational drug use. Methods：About 227 ADR reports caused by antibacterials were collected and analyzed retrospectively in our hospital from Jan. 2008 to Jan. 2011. Results：Among the 227 ADR cas- es, there were more male＇s ADR reports than female＇s and 40.53% was the patients over sixty years old. Most ad- verse reactions were induced by quinolones （42.29%） and [3-1actams （24.67%）, and the most common clinical mani- festations were the damage of skin and appendages （38.77%） and digestive system lesion （25.55%）. Conclusion ： Hospi- tals should pay more attention to the rational drug use and the management of antibacterials, as well as the ADR mon- itoring.