| 卡介苗接种后发生感染的可能原因研究现况 |
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| 引用本文： | 陈柠,孙琳,申阿东,何秋水.卡介苗接种后发生感染的可能原因研究现况[J].中国防痨通讯,2020,42(8):869-873. |
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| 作者姓名： | 陈柠 孙琳 申阿东 何秋水 |
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| 作者单位： | 100069.北京,首都医科大学基础医学院病原生物学系[陈柠、何秋水(外籍教授)];首都医科大学附属北京儿童医院 北京市儿科研究所 儿科学国家重点学科 教育部儿科重大疾病研究重点实验室 国家呼吸系统疾病临床医学研究中心 儿童呼吸道感染性疾病研究北京市重点实验室(孙琳、申阿东);芬兰图尔库大学医学微生物和免疫学系(何秋水) |
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| 基金项目： | “十三五”国家科技重大专项(2017ZX10202101-004-001);“十三五”国家科技重大专项(2018ZX10715005-004-006);北京市自然科学基金(19L2043) |
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| 摘 要： | 卡介苗是用于预防结核病的减毒活菌疫苗。虽然卡介苗被认为是最安全的疫苗之一,但仍会出现一些不良反应,其中最严重的是全身播散性卡介苗感染。虽然卡介苗相关感染的发病率低,但预后较差,严重者可致死。因此,加强对卡介苗接种后发生相关感染的认识,特别是对其发病原因的研究,有助于为卡介苗接种和临床疾病的救治提供帮助。
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| 关 键 词： | 结核 肺 卡介苗 接种 分枝杆菌感染 先天免疫缺陷病 孟德尔遗传易感分枝杆菌病 |
| 收稿时间： | 2020-06-07 |
Possible causes of infection after BCG vaccination |
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| CHEN Ning,SUN Lin,SHEN A-dong,HE Qiu-shui.Possible causes of infection after BCG vaccination[J].The Journal of The Chinese Antituberculosis Association,2020,42(8):869-873. |
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| Authors: | CHEN Ning SUN Lin SHEN A-dong HE Qiu-shui |
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| Institution: | Department of Medical Microbiology, College of Basic Medicine, Capital Medical University,Beijing 100069, China (;Foreign Professor, Work in Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland) |
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| Abstract: | Bacillus Calmette-Guérin (BCG) is an attenuated live bacterial vaccine used for prevention of tuberculosis. Although BCG is proven to be one of the safest vaccines, there are still some adverse reactions. The most severe complication is systemically disseminated BCG infection. Although incidence of BCG-related infections is low, the prognosis is poor and severe cases can be fatal. Therefore, strengthening the understanding of possible causes of BCG-related infections is important for improved BCG vaccination and clinical treatment of these infections. |
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| Keywords: | Tuberculosis pulmonary BCG vaccine Vaccination Mycobacterium infections Primary immunodeficiency disease Mendelian susceptibility to mycobacterial disease |
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