氯法齐明治疗结核病的临床应用指南

氯法齐明作为治疗耐药结核病的核心药物之一,由于缺乏规范性指导意见,中国防痨协会临床试验专业分会与《中国防痨杂志》编辑委员会组织相关专家制定本指南。本指南介绍了氯法齐明的分子结构与作用机制、药效学与药代动力学、耐药机制、不同类型人群的临床应用、适应证与禁忌证、剂量用法、化疗方案的制订,以及不良反应和临床应用注意事项等内容,以期对临床规范使用氯法齐明起到指导性作用。

Guideline for clinical application of clofazimine in the treatment of tuberculosis

Clofazimine, as one of the core drugs for the treatment of drug-resistant tuberculosis, lacks regulatory guideline. The Clinical Trial Branch of the Chinese Antituberculosis Association and the Editorial Board of Chinese Journal of Antituberculosis organized relevant experts to develop this guideline. This guideline formulated the molecular structure, mechanism of action, pharmacodynamics and pharmacokinetics, mechanism of drug resistance, indications and contraindications, dosage, chemotherapy regimen, adverse effect and precautions for clinical application to guide the clinical application for different population with clofazimine in practice.