放置时间对两种青霉素类抗菌药物微粒数的影响

目的 研究放置时间对我院静脉用药调配中心(简称PIVAS)配制的注射用哌拉西林钠/三唑巴坦钠和注射用美洛西林钠/舒巴坦钠稳定性及不溶性微粒数的影响。方法 跟踪并记录我院PIVAS 2018年6月18日-24日上午长期医嘱抗菌药物放置时间，通过整理和计算得到相关数据。取注射用哌拉西林钠/三唑巴坦钠和注射用美洛西林钠/舒巴坦钠按一定浓度配制后，分别检测于室温下放置0、1、2、3和4h的不溶性微粒数，探讨放置时间对我院PIVAS配制的两种抗菌药物不溶性微粒数的影响。结果 收集抗菌药物医嘱1917例，其中放置时间≤1h的医嘱占2.8%，放置时间1~2h的医嘱占71.1%，放置时间2~3h的医嘱占20.8%，放置时间3~4h的医嘱占3.7%，放置时间＞4h的占1.5%，最大放置时间5.3h。不溶性微粒数检测显示，两种复配后的抗菌药物配伍液中，粒径≥10μm的微粒数在放置时间达到1h时均有所降低，且具有统计学意义(P＜0.05)。随着放置时间增加，两种配伍液中粒径≥25μm和≥10μm微粒数仍呈减少趋势，但无统计学意义(P＞0.05)。≥25μm的微粒数在4h内无统计学差异(P＞0.05)。结论 注射用哌拉西林钠/三唑巴坦钠和注射用美洛西林钠/舒巴坦钠放置时间在4h内不会造成微粒数增加，反而放置1h后微粒数减少，该现象有利于降低静脉炎等不良反应发生的几率。

Impact of different standing time on insoluble particles of two penicillin-like antibiotics#br#

Objective To study the impact of different standing time on (piperacillin sodium and tazobactam sodium) and (mezlocillin sodium and sulbactam sodium) stability and the number of insoluble particles of PIVAS in our hospital. Methods We tracked and recorded the placement time of antibiotics prescribed by our hospital PIVAS from the morning of June 18, 2018 to June 24, 2018, and obtained relevant data through collation and calculation. After the injection (piperacillin sodium and tazobactam sodium) and (mezlocillin sodium and sulbactam sodium) were prepared at a certain concentration, the number of insoluble particles at room temperature at 0, 1, 2, 3, and 4h was detected, and the effect of the standing time on the number of insoluble particles of two antibacterial drugs configured with PIVAS in our hospital was discussed. Results A total of 1,917 cases of antibacterial drugs were collected, among which standing time less than 1h accounted for 2.8%, 1~2h accounted for 71.1%, 2~3h accounted for 20.8%, 3~4h accounted for 3.7%, more than 4h accounted for 1.5%, and 5.3h was maximum standing time. The insoluble particle count test showed that in the two antibacterial drugs after configuration, the number of particles ≥10μm decreased significantly at the time of 1h, and the results were statistically significant (P＜0.05). With the increase of standing time, the number of particles in the compatible solution still showed a decreasing trend, but there was no statistical significance (P>0.05). There was no statistical difference within 4h of particles with diameters ≥25μm(P>0.05). Conclusions (Piperacillin sodium and tazobactam sodium) and (mezlocillin sodium and sulbactam sodium) did not cause particle number increase within 4h. The particle number decreases after 1h, which can reduce the probability of adverse reactions such as