黑种草方剂的组成、功效及临床应用研究进展

黑种草是毛茛科黑种草属一年生草本植物，在国内外食品、药品、香料等行业应用广泛，是药食同源植物。因其籽粒中富含皂苷、黄酮、生物碱等多种生物活性成分而具有丰富的药理作用，也是中药方剂的常用配伍药材之一。本文搜集了含黑种草子的傣、蒙、藏、维药方剂，对其组成和功效进行了归纳总结，并运用IBM SPASS Modeler 18数据挖掘软件分析了方剂中常用药材使用频率和高频用药药对配伍关系，以期为黑种草的后续研究和含黑种草子方剂的成药开发提供参考。

Research Progress on the Composition, Efficacy and Clinical Application of Prescriptions Containing Nigella Damascena L.

Danshensu (DSS), one of the most important water-soluble components. It has the effects of scavenging reactive oxygen species (ROS), antioxidant stress, improving myocardial ischemia and hypoxia, myocardial ischemia-reperfusion(I/R) injury, and improving microcirculation. DSS can be used to protect against myocardial ischemia and protect endothelial cells from inflammatory responses. The development and synthesis of danshensin derivatives with higher pharmacological activity, better stability and lipid solubility have become a research hotspot in recent years. In this paper, the advances in pharmacological action, molecular mechanism, derivative research and dosage form application of danshensu in recent years were reviewed in order to make a more comprehensive and in-depth understanding of danshensu application and clinical research.