老年急性髓系白血病化疗方案探讨

目的:探讨老年急性髓系白血病(AML)化疗方案。方法:选择我院2001-06～2011-06收治的老年AML患者(>60岁)64例进行分析,按照治疗方案分为2组,A组(亚标准剂量组),B组(预激方案组),并对2组患者疗效进行比较。结果:只有58例可进入疗效评价。A组33例,15例获完全缓解(CR),CR率为45.5%,B组25例,10例获CR,CR率为40.0%,2组CR率比较无统计学意义(P>0.05)。结论:亚标准剂量组相对老年患者而言化疗剂量较大,治疗相关病死率增加。减低剂量的CAG预激方案对老年AML患者来说有一个好的缓解率及总生存时间。

Chemotherapy strategy in elderly patients with acute myelogenous leukemia

Objective:To explore the chemotherapy strategy in elderly patients with acute myelogenous leukemia(AML).Methods: A total of 64 patients aged 60 years with AML from 2001 to 2011 were analyzed,the patients were divided into two groups,group A(substandard-dose regimen group,n=33),group B(preexcitation regimen group,n=25).The therapeutic effect of the patients were compared.Results: Only 58 patients entered into our study.The complete remission(CR) of group A and B was 45.5 % and 40.0 % respectively.There was no significant difference in CR rate between the two groups(P>0.05).Conclusion: The chemotherapy dose of substandard-dose regimen group is excessive to elderly patients,the treatment related mortality is increased.The remission rate and total survival time is better in low dose preexcitation regimen group.