老年高血压病血压昼夜节律异常与靶器官损害

目的：了解并探讨老年高血压病（HPE）血压昼夜节律改变与靶器官损害（TOD）的关系及临床特点，方法：对126例HPE患和84例非老年高血压病（HPNE）患进行24小时动态血压监测（ABPM），并比较其结果。结果：HPE组昼夜节律异常发生率明显高于HPNE组（P＜0．01），HPE组昼夜节律异常并发症发生率明显高于昼夜节律正常，也明显高于HPNE组昼夜节律异常或正常（P均＜0．01），HPE组昼夜节律异常的心胸比值，QRS波振幅时间乘积及血肌酐水平明显大于其余各组，而肌酐清除率明显降低（ P均＜0．01），结论：HPE昼夜节律的改变对TOD的影响较HPNE组更显，对于HPE患，恢复其正常昼夜节律是治疗的关键。

Correlation between abnormal circadian variation of blood pressure and target-organ damage in elderly hypertension

Objective:To study relationship between abnormal circadian variation of blood pressure(BP) and target|organ damage in elderly hypertension(HPE).Methods:Ambulatory BP monitoring was performed in 126 cases of HPE and 84 cases of nonelderly hypertension(HPNE).Results:The rate of abnormal BP circadian variation in the HPE was higher than those of HPNE group(P<001).The rate of complication in HPE with abnormal BP circadian variation was higher than those of HPE with normal BP circadian variation and HPNE(with normal or abnormal BP circadian variation),P<001 all.Conclusion:Influence of HPE with abnormal BP circadian variation on target|organ damage is more than that in HPNE group.Recover BP circadian variation to normal is the key of therapy.