| bcl-2、Ki-67和p53在Wilms瘤中的表达 |
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| 引用本文： | 吴小燕,徐联芳,熊永炎,曾俊,李爽. bcl-2、Ki-67和p53在Wilms瘤中的表达[J]. 医学新知杂志, 2000, 10(4): 205-206 |
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| 作者姓名： | 吴小燕 徐联芳 熊永炎 曾俊 李爽 |
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| 作者单位： | 1. 湖北医科大学附属第二医院内科,武汉,430071
2. 武汉市儿童医院外科,武汉,430016 |
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| 摘 要： | 为研究Ｗｉｌｍｓ瘤的发病机制，采用Ｓ－Ｐ法对３０例Ｗｉｌｍｓ瘤石蜡组织进行ｂｃｌ－２、Ｋｉ－６７和ｐ５３蛋白检测。结果ｂｃｌ－２、Ｋｉ－６７和ｐ５３阳性率分别为１０．０％、１３．３％和２０．０％，正常对照组织中无１例表达。提示ｂｃｌ－２基因的活化在该肿瘤发病中有一定启动作用；Ｋｉ－６７阳性表达与肿瘤的分化程度和临床预后不良有关；ｐ５３过度表达多发生于Ｗｉｌｍｓ瘤临床早期，但三者间关系需进一步研究。
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| 关 键 词： | 癌基因 表达 肾肿瘤 bcl－2 Ki－67 p53 |
Expressions of bcl-2,Ki-67 and p53 in Wilms Tumour |
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| Wu Xiao yan,Xu Lianfang,Xiong Yongyan,et al nd Affiliated Hospital,Hubei Medical University,Wuhan. Expressions of bcl-2,Ki-67 and p53 in Wilms Tumour[J]. Journal of New Medicine, 2000, 10(4): 205-206 |
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| Authors: | Wu Xiao yan Xu Lianfang Xiong Yongyan et al nd Affiliated Hospital Hubei Medical University Wuhan |
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| Affiliation: | Wu Xiao yan,Xu Lianfang,Xiong Yongyan,et al 2nd Affiliated Hospital,Hubei Medical University,Wuhan 430071 |
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| Abstract: | To investigate the pathogenesis of Wilms tumour,the expression of bcl 2,Ki 67 and p53 were detected by immunohistochemistry (SP) in 30 cases.The results showed that the positive rates of bcl 2,Ki 67 and p53 were 10.0% , 13.3% ,20.0% respectively.No positive case was found in normal group. The results indicated that apoptosis suppression plays a role in Wilms tumour,Ki 67 positive reaction is correlative with cell differentiation and prognosis,p53 over espression is occurred in early clinical stage of wilms tumour. |
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| Keywords: | Oncogene Expression Renal tumour |
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