| 紫外诱变复合重金属离子抗性突变选育霉酚酸高产菌株 |
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| 引用本文： | 娄忻,贾啸静,刘胜利,张华.紫外诱变复合重金属离子抗性突变选育霉酚酸高产菌株[J].中国抗生素杂志,2007,32(9):536-537. |
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| 作者姓名： | 娄忻 贾啸静 刘胜利 张华 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,微生物药物国家工程研究中心,石家庄050015 |
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| 摘 要： | 以霉酚酸产生菌1321#为出发菌株,采用紫外线诱变并复合重金属Cr6 、Cu2 抗性株筛选,获得一株遗传性状稳定且摇瓶发酵水平提高86.6%的164#高产菌株。经发酵配方优化,该菌株的摇瓶单位再度提升了5.5%,显示出了高产潜力。
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| 关 键 词： | 霉酚酸 诱变 重金属离子 抗性筛选 |
| 文章编号： | 1001-8689（2007）09-0536-02 |
| 修稿时间： | 2007-01-20 |
Screening mycophenoilc acid high producing strain with UV and heavy metal ion resistance mutation |
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| Lou Xin,Jia Xiao-jing,Liu Sheng-li,Zhang Hua.Screening mycophenoilc acid high producing strain with UV and heavy metal ion resistance mutation[J].Chinese Journal of Antibiotics,2007,32(9):536-537. |
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| Authors: | Lou Xin Jia Xiao-jing Liu Sheng-li Zhang Hua |
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| Abstract: | A mycophenoilc acid(MPA) producing strain Penicillium brevicompactum #1321 was treated by UV,followed by resistance selection with heavy metal Cr6 and Cu2 .A stable strain #164 was obtained with the potency of MPA higher by 86.6% than starting strain in shaking culture.The potency was further improved by 5.5% in the optimized fermentation medium. |
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| Keywords: | Mycophenoilc acid Mutagenesis Heavy metal ion Resistant screening |
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