血清超敏C-反应蛋白与动脉粥样硬化血栓形成性脑卒中的相关性研究

目的:探讨血清超敏C-反应蛋白(hsCRP)水平对动脉粥样硬化血栓形成性脑卒中发生风险的预测价值。方法:采用病例-对照研究,按照TOAST分型标准,纳入动脉粥样硬化血栓形成性脑卒中患者114例为病例组,同时随机抽取门诊体检人群中无心、脑及周围动脉粥样硬化病史者130例为对照组;记录动脉粥样硬化危险因素及影响hsCRP的潜在危险因素;酶联免疫吸附法测定血清hsCRP水平,比较两组间基线hsCRP水平,并将hsCRP水平进行分层(<3mg/mL,3～10mg/mL,>10mg/mL),多因素Logistic回归模型分析不同hsCRP水平患者发生动脉粥样硬化血栓形成性脑卒中的风险。结果:病例组血清hsCRP水平高于对照组(P=0.001),校正相关危险因素后,血清hsCRP水平仍高于对照组(P=0.021);以hsCRP水平以<3mg/mL为基准,未校正任何危险因素,不同水平的hsCRP预测发生动脉粥样硬化血栓形成性脑卒中的OR值依次为1.000、2.429、5.634(P<0.05),校正相关危险因素后,OR值依次为1.000、2.005、4.277(P<0.05)。结论:hsCRP水平越高,动脉粥样硬化血栓形成性脑卒中发生风险越高。

Correlation between High Sensitivity C-reactive Protein and Atherothrombosis Stroke

Objective: To explore the correlation between high sensitivity C-reactive protein(hsCRP) and atherothrombosis strokes.Methods: One hundred and forty-four patients with atherothrombosis strokes and 130 patients without history of strokes and relevant vascular diseases(controls) were enrolled for the study respectively.All demographic parameters and associated risk factors of characteristic in questionnaire are collected.The serum hsCRP level was assessed by enzyme-linked immunosorbent assay.According to hsCRP levels of below3,3~10,and above 10 mg/L,we performed logistic regression and stratification analysis to evaluate the correlation between hs-CRP at different stages with atherothrombosis strokes.Results: The hsCRP level of the patients group was higher than that in the control group(P=0.001).After adjustment for related risk factors,hsCRP level in the patients was still higher than that in the control group(P=0.021).As compared with the lowest quartile of hsCRP level,OR in turn was 1.000,2.429,and 5.634 respectively(P<0.05).After correcting related risk factors,OR in turn was 1.000,2.005,and 4.277 respectively(P<0.05).Conclusion: A higher hsCRP level indicates a higher risk of atherothrombosis strokes.