富硒板党对小鼠CCl4致肝损伤的保护作用探讨

目的探讨富硒板党对小鼠四氯化碳（CCl4）致肝损伤的保护作用。方法采用CCl4致小鼠急性肝损伤模型，测定血清谷丙转氨酶（ALT）、谷草转氨酶（AST），肝组织丙二醛（MDA）、超氧化物歧化酶（SOD）活性变化。结果富硒板党能保护CCl4所致小鼠肝损伤，表现为血清ALT，AST含量降低（P〈0.05或P〈0.01）和肝脏MDA含量下降（P〈0.01），SOD活性增强（P〈0.05或P〈0.01）。结论富硒板党对CCl4所致小鼠肝损伤具有保护作用。

Protective effect of rich selenium-banqiao-codonopsis pilosula on liver injury induced by CCl4 in mice

Objective To investigate the protective effect of rich selenium-banqiao-codonopsis pilosula on liver injury induced by CCl4 in Mice. Methods The acute hepatic injury model was prepared by CCl4 injected intraperitoneally. Then, the therapeutic effects of rich selenium banqiao codonopsis pilosula on the model were evaluated by the activity determination of serum alanine aminotransferase（ALT and AST）,superoxide dismutase（SOD） and the content of malondialdehyde（MDA） in liver. Results Rich selenium-banqiao-codonopsis pilosula significantly reduced seruln ALT, AST activities （ P 〈 0.05 or P 〈 0.01） and liver MDA content （ P 〈 0.01 ） ; SOD activity was obviously increased （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Rich selenium ban-qiao codonopsis pilosula has a potective effect on the acute hepatic injury induced by CCl4 in mice.