胺碘酮、普罗帕酮、美托洛尔治疗阵发性室上性心动过速疗效观察

目的 探讨胺碘酮、普罗帕酮、美托洛尔3种药物分别静脉注射终止阵发性室上性心动过速（PSVT）发作的疗效及安全性。方法将我院急诊和住院治疗的73例PSVT患者,随机分成胺碘酮组（30例）、普罗帕酮组（22例）和美托洛尔组（21例）,分别缓慢静脉注射胺碘酮、普罗帕酮或美托洛尔,比较终止PSVT的有效性及不良反应。结果胺碘酮组治疗后有效23例,无效7例,有效率76．7％;普罗帕酮组治疗后有效17例,无效5例,有效率77．3％;美托洛尔组治疗后有效17例,无效4例,有效率81．O％,3组治疗PSVT的疗效比较,差异无统计学意义（P〉0．05）。未观察到3组治疗后有明显的不良反应。结论3种药物都能安全、有效地终止PSVT。

Observation of theraputic effects of three drugs on paroxysmal suprarentricular tachycardia

Objective To evaluate the effectiveness and security of intravenous injection admiodarane, propafenone and metoprolol on terminating paroxysmal supraventrieal tachyeardia. Methods 73 patients of PSVT who had hospitalized or was in emergency in our hospital were random divided 3 groups： admiondarane group （30 subjects ）, propofenone group （22subjects） and metoprolol group（21subjects）. They were given admiodarane, propafenone or mentoprolol by intravenous injection. Finally, to compare the effectiveness and adverse reaction of these drugs on concluding PSVT. Results Among 30 patients in admiodarane group, the medicine showed effective in 24 patients and ineffective in 7 patients, and effective rate was 76.7%. Among 22 patiens in propafenone group, the medicine showed effective in 17 patients and ineffective in 5 patients, and the effective rate was 77.3%. Among 21 patients in metoprolol group, the mendicine showed effective in 17 patients and ineffective in 4, and the effective rate was 81.0%. There was no significant difference among three groups （P 〉 0. 05 ）. Few ill effects have been detected during the process. Conclusion These drugs all were effective and safe on acute termination of paroxymal supraventrical tachycardia.