HLA-B27检测在强直性脊柱炎诊断中的临床价值

目的 探讨HLA-B27抗原检测在强直性脊柱炎（AS）早期诊断中的临床价值。方法使用ELISA法对450例健康体检者（非AS对照组）、462例AS疑似患者（AS疑似组）和80名AS患者（AS组）进行HLA-B27抗原检测。结果非AS对照组、AS疑似组和As组的HLA—B27阳性率分别为3．3％、48．9％和92．5％,AS组、AS疑似组的HLA—B27阳性率明显高于非AS对照组（P〈0．01）,AS组的HLA—B27阳性率明显高于AS疑似组（P〈0．01）。结论HLA．B27抗原与AS疾病相关,检测HLA—B27抗原对疑似AS患者的早期诊断有重要意义。

The clinical value of HLA-B27 in the diagnosis of ankylosing spondyfitis

Objective To explore the clinical value of HLA-B27 inpatients with ankylosing spondyfitis. Methods Using ELISA to detect the HLA-B27 of 450 healthy people （non -AS group） ,462 presumed AS patients （suspectable group） and 80 AS patients（ AS group）. Results The positive rate of HLA-B27 of non-AS patients,presumed AS patients and AS patients was 3.3% ,48. 9% and 92.5% respectively. The positive rate of HLA-B27 of AS patients was significantly higher than that of non-AS patients（ P 〈 0.01 ）. The positive rate of HLA-B27 of AS patients was significantly higher than that of presumed AS patients（ P 〈 0. 01 ）. Conclusion There is positive correlation between AS and HLA-B27. It is very important for the early diagnosis of AS.