丙种球蛋白治疗新生儿ABO溶血病疗效观察

目的：观察大剂量静脉输注丙种球蛋白（IVIG）治疗新生儿ABO溶血病的疗效。方法：对63例ABO溶血病患儿随机分为治疗组（35例）和对照组（28例），治疗组给予常规治疗＋大剂量IVIG治疗，对照组仅给予常规治疗，分别监测血清总胆红素和血红蛋白，记录两组患儿的光疗时间及黄疸消退时间。结果：治疗组的血清总胆红素显著低于对照组[（112.50±50.43）ummol/L VS（202.50±60.51）ummol/L,P〈0.05]，光疗时间[（29.25±15.43）h VS（41.46±17.54）h, P〈0.05]及黄疸消退时间[（4.52±1.41）h VS （6.15±1.67）h,P〈0.05）]较对照组明显缩短，差异均有统计学意义。两组间血红蛋白无明显差异，但对照组的血红蛋白较治疗组有下降趋势。结论：应用丙种球蛋白治疗新生儿ABO溶血病，可有效降低血清总胆红素，缩短患儿的光疗时间及黄疸消退时间。

Curative Effect Observation of Gamma Globulin in Treatment of Neonatal ABO-hemolytic Disease

Objective：To observe the curative effect of large-dose intravenous immunoglobulin（IVIG） in treatment of neonatal ABO-hemolysis.Methods：63 cases of ABO-hemolysis were randomly divided into 2 groups,35 cases in treatment group and 28 cases in the contral group. The treatment groupWas given both routine therapy and large-dose IVIG, while the control group was given only routine therap,monitoring the serum total bilirubin and hemoglobin, recording the phototherapy time and jaundice regression time. Results：The total serum bilirubin of treatment group was significantly lower than control group （112.50±50.43 ummol/L VS 202.50±60.51 ummol/L,P〈0.05）.The photother-apy time（29.25±15.43 h VS 41.46±17.54 h, P〈0.05） and jaundice regression time（4.52±1.41 h VS 6.15±1.67 h, P〈0.05） of treatment group were significantly shorter than those of control group.The hemoglobin of 2 groups have no significant differences, but the hemoglobin of contral group have a downward trend when compared with the treatment group.Conclusion：Gamma globulin is effective for neonatal ABO-hemolysis in reducing the level of total serum bilirubin,the duration of phototherapy and the regression time of jaundice.