急性颅脑损伤患者体液内皮素-1 表达的意义简

目的：探讨急性颅脑损伤患者脑脊液及血清内皮素-1（endothelin-1， ET-1）含量及其临床意义。方法36例急性颅脑损伤患者以GCS评分分组（20例GCS≤12分患者为中、重型颅脑损伤组、16例GCS＞12分患者为轻度颅脑损伤组）；选择同期住院的非神经系统疾病手术患者19例为对照组。两组患者采用双抗体夹心（ ELISA ）法检测脑脊液和血清的ET-1浓度。结果中、重度颅脑损伤组血清ET-1浓度高于轻度损伤组（ P ＜0．01）和对照组（ P ＜0．01）；轻度颅脑损伤组血清ET-1浓度高于对照组（ P ＜0．01）。中、重度颅脑损伤组脑脊液ET-1浓度高于轻度损伤组（ P ＜0．01）和对照组（ P ＜0．01）；轻度颅脑损伤组脑脊液ET-1浓度高于对照组（ P ＜0．05）。所有研究对象中，血清ET-1浓度高于脑脊液（ P ＜0．01）。结论急性颅脑损伤患者脑脊液及血清ET-1水平均明显升高，并且与颅脑损伤的程度密切相关。

Significance of endothelin-1 expression in serum and CSF in patients with acute craniocerebral injury

Objective To elucidate clinical significance of the varied concentration of cytokines in patients with acute cranio -cerebral injury, the concentration of endothelin-1 （ET-1） in cerebrospinal fluid （CSF） and serum.Methods In this study, 36 pa-tients with acute craniocerebral injury were divided into two groups by their GCS scores （ GCS≤12 ） as moderate-severe injury group （n =20） and GCS＆gt;12 as mild injury group（ n =16）.Concentration of ET-1 in CSF and serum in 36 patients with acute craniocere-bral injury were detected by ELISA .Results The concentration of ET-1 in CSF in moderate to severe patients , which was significantly higher than that of the mild injury group （ P 〈0.01） and control group（ P 〈0.01）.And the levels of ET-1 in CSF in the mild injury group were also obviously higher than that of the control group （ P 〈0.01）.On the other hand, the concentration of ET-1 in moderate to severe patients , which was also significantly higher than that of the mild injury group （ P 〈0.01） and control group（ P 〈0.01）. And the levels of ET-1 in serum in the mild injury group were obviously higher than that of the control group （ P 〈0.05）.The concen-tration of ET-1 in serum was significantly higher than that of CSF （ P 〈0.01）.Conclusion The concentration of ET-1 in CSF and ser-um in patients with acute craniocerebral injury may be closely associated with the levels of acute craniocerebral injury .