中老年女性腰围、腰臀比及高血压与子宫肌瘤关系

目的探讨中老年女性腰围（WC）、腰臀比（WHR）及高血压与发生子宫肌瘤（uL）危险性的关系．方法采用以医院为基础的研究方法，选择612例35。65岁女性，患者均经超声诊断或手术确诊的子宫肌瘤患者．对照组为因患其他疾病同期人住与病例相同医院的患者。采用调查表对研究对象进行调查．包括人口学特征、生活方式以及既往史等，同时对身高、体重、WE及臀围进行测量。采用多因素Logistie回归模型对患者WE、WHR及高血压与UL的比值比（OR）及其相应的95％CI进行估计。结果WC和WHR升高使发生UL的危险性增加（OR：1．504，95％CI：1．068-2．119，P=0．019；OR=1．524，95％CI：1．107—2．097，P=0．010）；罹患高血压的女性与UL呈正相关（OR=1．505，95％CI：1．046～2．165，P=0．028）。与收缩压为最低四分位数的对照相比，第3个四分位数的病例发生UL的危险性较高（OR=I．675，95％CI：1．053～2．663，P=0．029）。当调整了多种潜在性混杂因素后．WE、WHR及高血压与UL关系的结果并未发生改变。结论向心性肥胖和高血压可能是发生UL的重要危险因素．

Waist circumference,waist to hip ratio,hypertension and the risk of uterine leiomyomata in middle and old agedwomen

Objective To explore the association between waist circumference （WC）, waist to hip ratio （WHR）, hypertension and uterine leiomyoma （UL） risk in middle aged and elderly women. Methods A hospital-based study was conducted. Cases （n=306） were confirmed by surgery.The age of these cases were 35~65 years old. 306 women admitted to the same hospital for different diseases not related with UL were used as controls. Data were collected using a structured interviewer-administrated questionnaire including information on socio-demographic characteristics, lifestyle habits, detailed medical history, simultaneously, all subjects were interviewed, and their height, weight, waist and hip circumference were measured. The odds ratios （OR） and 95% confidence intervals （CI） of UL for WC, WHR, and hypertension were estimated by unconditional multiple logistic regression models. Results It was shown that the increased UL risk was related to the increasing of WC and WHR. Hypertension was positively associated with UL. Compared to women in the lowest quintile of systolic pressure, the OR for women in the third quintile of systolic pressure was 1.675. After adjusted for multiple potential confounders, the results of WHR, WC and hypertension remained unchanged. Conclusion Central obesity and hypertension may be risk factors for UL.