神经生长因子治疗脑出血的临床疗效观察

目的观察鼠神经生长因子(NGF)治疗脑出血的临床疗效。方法选择脑出血患者119例,随机分为对照组63例和NGF组56例,在常规治疗基础上,2组分别给予胞磷胆碱或鼠NGF制剂治疗2周,分别于治疗后1、2周,采用美国国立卫生研究院卒中量表(NIHSS)评分评价2组患者的神经功能缺损情况,采用Barthel指数(BI)评价患者的日常生活活动能力。结果治疗后,2组患者的NIHSS评分均较治疗前显著降低(P<0.01),BI均较治疗前显著增加(P<0.01);治疗后1周,2组NIHSS评分及BI差异无统计学意义(P>0.05);治疗后2周,NGF组患者的NIHSS评分明显低于对照组,BI明显高于对照组(P<0.01)。结论 NGF治疗可以有效缓解脑出血患者的神经功能缺损,改善患者的日常生活活动能力。

Clinical curative effect of nerve growth factor on cerebral hemorrhage

Objective To observe the curative effect of nerve growth factor(NGF) on cerebral hemorrhage.Methods One hundred and nineteen patients with cerebral hemorrhage were randomly divided into control group(n=63) and NGF group(n=56).The patients were treated with cytidine diphosphate or NGF for 2 weeks after routine treatment.Nerve dysfunction was scored for the two groups following the NIHSS and the activities of daily living were assessed for the two groups according to the Barthel index(BI) 1 and 2 weeks after treatment.Results The NIHSS score was significantly lower whereas the BI was significantly higher in the two groups after treatment than before treatment(P<0.01).No significant difference was found in the NIHSS score between the two groups 1 week after treatment(P>0.05).The NIHSS score was significantly lower whereas the BI was significantly higher in NGF group than in control group(P<0.01).Conclusion NGF can effectively alleviate the nerve dysfunction and improve the activities of daily living of patients with cerebral hemorrhage.