Nonalcoholic fatty liver disease and risk of prostatic diseases: Roles of insulin resistance |
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| Authors: | Shankun Zhao Yaoyao Wang Weizhou Wu Suqing Yang Lili Feng Fangfang Tao Weiwei Ge Maolei Shen Weifang Xu |
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| Institution: | 1. Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China;2. Second School of Clinical Medicine, Wenzhou Medical University, Wenzhou, China;3. Department of Urology, Maoming People's Hospital, Maoming, China;4. Department of Orthopedics, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China;5. Nursing Department, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China |
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| Abstract: | Nonalcoholic fatty liver disease (NAFLD), the liver component of metabolic syndrome, is considered to be associated with high risk of prostatic diseases but a systematic review has not been conducted. Under a comprehensive review of the eligible clinical studies, a potential positive association between NAFLD and benign prostatic hyperplasia/prostate cancer (BPH/PCa) has been postulated. Insulin resistance and metabolic aberrations are considered to be the potential mechanism for such association. However, the relationship between NAFLD and other prostatic diseases, that is, prostatic inflammation and lower urinary tract symptoms, seems vague due to limited relevant studies in the literatures. The present review highlights that clinicians should be conscious of the detrimental effect of NAFLD on the development of BPH and PCa. |
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| Keywords: | benign prostatic hyperplasia lower urinary tract symptoms nonalcoholic fatty liver disease prostate cancer prostatic diseases |
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