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A report of pregnancy following ICSI in one of two sisters with familiar primary ciliary dyskinesia |
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| Authors: | Fahimeh Akbarian Marziyeh Tavalaee Roya Sherkat Mohammad Shahrooei Mohammad Hossein Nasr-Esfahani |
| Affiliation: | 1. Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran;2. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran |
| Abstract: | Primary ciliary dyskinesia (PCD) is a disorder of structure and function of motor ciliary and dyskinetic activity of ciliary in the fallopian tubes of affected women and could lead to infertility in some cases. In vitro fertilisation (IVF) is a choice of treatment in infertile women with PCD, which could conquer the tubal dysfunction. In this case study, we report a PCD affected woman with infertility who was treated by IVF and pregnancy was achieved but it failed due to the spontaneous abortion. We also performed whole-exome sequencing for this case and her PCD-affected sister, which did not reveal any genetic abnormality related to the PCD or infertility. |
| Keywords: | in vitro fertilisation intrauterine insemination pregnancy primary ciliary dyskinesia |