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Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites
Authors:Noora Ottman  Mauricio Barrientos-Somarribas  Nanna Fyhrquist  Helen Alexander  Lukas Wisgrill  Peter Olah  Sophia Tsoka  Dario Greco  Francesca Levi-Schaffer  Vassili Soumelis  Jens M. Schröder  Juha Kere  Frank O. Nestle  Jonathan Barker  Annamari Ranki  Antti Lauerma  Bernhard Homey  Björn Andersson  Harri Alenius
Affiliation:1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;2. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;3. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Human Microbiome Research Program, University of Helsinki, Helsinki, Finland;4. St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK;5. Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria;6. Department of Dermatology, University Hospital Duesseldorf, Duesseldorf, Germany

Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary;7. Department of Informatics, Faculty of Natural and Mathematical Sciences, King’s College London, London, UK;8. Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

Institute of Biomedical Technology, University of Tampere, Tampere, Finland

Institute of Biotechnology, University of Helsinki, Helsinki, Finland;9. Pharmacology Unit, School of Pharmacy, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel;10. Institut Curie, Paris, France

INSERM, Paris, France;11. Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany;12. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

School of Basic and Medical Biosciences, King’s College London, London, UK;13. Cutaneous Medicine Unit, St. John’s Institute of Dermatology and Biomedical Research Centre, Faculty of Life Sciences and Medicine, King’s College London, London, UK;14. St John’s Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, Kings College London, London, UK;15. Department of Dermatology, Allergology and Venereology, Inflammation Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;16. Department of Dermatology, University Hospital Duesseldorf, Duesseldorf, Germany

Abstract:
Keywords:atopic dermatitis  inflammation  microbiome
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