Healing of Fresh Extraction Sockets Filled with Bioactive Glass Particles: Histological Findings in Humans |
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| Authors: | Emanuele Clozza DDS Maurizio Pea MD Fabio Cavalli MD Loredana Moimas MEng PhD Roberto Di Lenarda DDS Matteo Biasotto DDS PhD MSc |
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| Affiliation: | 1. Resident, Ashman Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY, USA;2. Head, Department of Pathology, Ospedale Orlandi, Bussolengo, Verona, Italy;3. Director, Research Unit of Paleoradiology and Allied Sciences, Ospedali Riuniti di Trieste, Trieste, Italy;4. R&D manager, Inion Oy, Tampere, Finland;5. Full professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy;6. Assistant professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy |
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| Abstract: | ![]()
Purpose: The aim of the present study was to histologically evaluate fresh human sockets filled with bioactive glass after 6 months of healing. Materials and Methods: In 13 patients, 32 single extraction sites in the anterior area underwent socket ridge preservation procedure (RPP) with a bioactive glass (BioRestore?, Inion Oy, Tampere, Finland). At implant installation, 22 bone cores were trephined out and processed for histomorphometric and immunohistochemical analysis. Results: Newly formed immature bone around residual particles of bioactive glass was found in all 22 biopsies. The histomorphometry of the amount of bone, provisional matrix, and residual graft returned a mean ± SD value of 54 ± 31%, 37.9 ± 25.6%, and 8.1 ± 7.8, respectively, 6 months after RPP. Conclusion: The use of this grafting material in fresh extraction sockets appears to delay the healing processes of the alveolar bone; therefore, its indication as a material for RPP when implant placement is considered within 6 months after extraction should be revised. |
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| Keywords: | alveolar sites bioactive glass bone graft bone regeneration histology |
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