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Rheumatoid neutrophilic dermatosis with tense blister formation: A case report and review of the literature
Authors:Yumi Fujio MD  Takeru Funakoshi MD  Kaori Nakayama MD  Masayuki Amagai MD  Manabu Ohyama MD
Affiliation:Department of Dermatology, Keio University School of Medicine, , Tokyo, Japan
Abstract:
We report a 78‐year‐old woman with rheumatoid neutrophilic dermatosis (RND) presenting with tense blisters; an extremely rare manifestation of this condition. Systemic corticosteroid was of limited efficacy, while dapsone was effective. A literature review of four similar cases showed that tense blisters in this type of RND tended to appear on the lower extremities of aged, female rheumatoid arthritis patients. Of note, half of the cases were resistant to corticosteroids, as anti‐neutrophil agents are reported to be effective. Accordingly, it is important to recognise this unusual manifestation for the timely initiation of appropriate therapy.
Keywords:blister formation  bullous pemphigoid  neutrophilic dermatosis  rheumatoid arthritis
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