妊娠高血压综合征与血脂、载脂蛋白及脂蛋白(a)的关系

目的探讨妊娠高血压综合征(简称妊高征)患者血脂代谢水平的变化及其临床意义。方法测定正常孕妇及妊高征患者的血清甘油三脂(TG)、总胆固醇(TC)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及脂蛋白(a)水平。结果妊高征组血清TG(P<0.01)、ApoB(P<0.01)、LDL-C(P<0.05)及LP(a)(P<0.05)较正常孕妇显著升高,ApoAI、HDL-C则显著降低(P<0.05),TC在两组间差别无显著性意义(P>0.05)。在轻、中、重妊高征患者之间,ApoAI(P<0.05)及HDL-C(P<0.01)依次降低,组间比较有显著性意义,LDL-C(P<0.01)及LP(a)(P<0.01)依次升高,组间有极显著性差异。TG、TC和ApoB组间比较,差别无显著性意义。结论血脂代谢异常可能在妊娠高血压疾病的发病中起一定作用。

Role of serumlipid, apolipoproteinlevels and poprotein (a) in pregnancy-induced hypertension syndrome

Object To investigate the serum lipid, apolipoprotein and lipoprotein(a) levels in pregnancy-induced hypertension syndrome (PIH).Methods The levels of serum triglyceroles(TG), cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein AI(ApoAI) , apolipoprotein B (ApoB) and lipoprotein(a) in 80 patients(PIH group)and 80 normal pognant women (control group) were dertimined and compared.Results Serum TG and ApoB in PIH patients was significantly higher than that in normal pregnant women (P<0.01). LDL-C and LP(a) in PIH patients was significantly higher than that in normal pregnant women (P<0.05).Serum HDL-C and ApoAI levels were lower in PIH patients than that in normal pregnant women (P<0.05), No significant differences were Seen in the levels of serum TC between the groups of PIH patients and the groups of normal pregnant women. There was significant difference in the levels of serum HDL-C(P<0.01), ApoAI(P<0.05), LDL-C(P<0.01) and LP(a) (P<0.01) between the subgroups of PlH patients according to the severity of the disease.no significant difference in the levels of serum TG,TC and ApoB between the subgroups of PIH patients according to the severity of the disease. Conclusion The changes of serum lipid,apolipoprotein levels and LP(a) in PIH patents may play a role in the pathogenesis of this diseases.