MCPIP1和IL-17c在寻常型银屑病皮损中的表达

目的:检测MCPIP1和IL-17c在寻常型银屑病患者皮损中的表达。方法:Real-time PCR及免疫荧光检测45例寻常型银屑病患者皮损及19例正常皮肤中MCPIP1和IL-17c mRNA及蛋白表达水平,皮尔逊相关系数分析MCPIP1和IL-17c的相关性。结果:银屑病组MCPIP1、IL-17c mRNA相对表达量分别为0.8497±0.0661和0.4027±0.04158,对照组中分别为0.2921±0.06135和0.2374±0.02525,差异均有统计学意义(P0.05)。MCPIP1和IL-17c mRNA水平具有明显相关性(P0.05)。患者组皮损中MCPIP1和IL-17c的蛋白表达水平高于正常对照组。结论:MCPIP1和IL-17c可能共同影响寻常型银屑病的发生发展。

Expression of MCPIP1 and IL-17c in the lesions of the patients with psoriasis vulgaris

Objective: To detect the expression of MCPIP1 and IL-17c in the lesions of the patients with psoriasis vulgaris.Methods: The expression levels of MCPIP1 and IL-17c mRNA and protein in the lesions of the patients with psoriasis vulgaris and the normal skin samples in 19 controls were detected by Real-time PCR and immunofluorescence technique.The association between the levels of MCPIP1 and IL-17c in the patients were assessed by Pearson correlation coefficient.Results: The level of MCPIP1 and IL-17c in the lesions was 0.8497±0.0661 and 0.4027±0.04158, which was higher than those in controls (0.2921±0.06135 and 0.2374±0.02525) with significant differences (P<0.05).There was obvious correlation between the level of MCPIP1 and IL-17c mRNA.The protein level of MCPIP1 and IL-17c in the lesions was higher than that in normal controls.Conclusion: MCPIP1 can interact with IL-17c, which influences the development of psoriasis.