| 血管性痴呆的遗传学机制研究进展 |
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| 引用本文： | 曹宇,裴卉,刘美霞,刘建刚,李浩.血管性痴呆的遗传学机制研究进展[J].中国临床神经科学,2017(5):586-594. |
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| 作者姓名： | 曹宇 裴卉 刘美霞 刘建刚 李浩 |
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| 作者单位： | 中国中医科学院西苑医院,中国中医科学院老年病研究所,100091 |
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| 基金项目： | 国家自然科学青年基金(81603616)，北京市科技计划十病十药项目(Z171100001717016) |
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| 摘 要： | 血管性痴呆是仅次于阿尔茨海默病的第二大痴呆类型,其发病率逐年增加。血管性痴呆的发病机制尚未明确,目前认为其发病是环境和基因等多种复杂因素共同作用的结果。随着基因组测序技术的发展,近年来大量文献报道了与血管性痴呆相关的基因多态性位点。本文综述了与血管性痴呆发病的遗传因素,总结了目前已知与血管性痴呆发病相关的遗传学研究进展。
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| 关 键 词： | 血管性痴呆 遗传学 单核苷酸多态性 |
The Research Progress of Genetic Mechanisms of Vascular Dementia |
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| CAO Yu,PEI Hui,LIU Mei-xia,LIU Jian-gang,LI Hao.The Research Progress of Genetic Mechanisms of Vascular Dementia[J].Chinese Journal of Clinical Neurosciences,2017(5):586-594. |
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| Authors: | CAO Yu PEI Hui LIU Mei-xia LIU Jian-gang LI Hao |
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| Abstract: | Vascular dementia is the second most common form of senile cognitive impairment after Alzheimer's disease.Its etiology remains unclear.Genetic and environmental factors are two factors caused diseases.With the development of modem gene sequencing technology,an increasing number of genetic variations have been reported.The most recent genetic risk factors associated with vascular dementia were reviewed,and an insight into the underlying mechanisms were given. |
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| Keywords: | vascular dementia genetics single nucleotide polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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