孕妇血清瘦素水平的测定

目的　探讨孕妇血清瘦素水平的变化及其与妊娠的关系。方法　采用放射免疫测定法 ,测定 2 5 1例孕妇 (观察组 )和 35例年龄、体重指数相近的正常非孕妇女 (对照组 )的血清瘦素水平 ,并将瘦素水平与孕妇的孕周、体重、体重指数、腹围、子宫底高度、血压等的关系进行了相关分析。结果　观察组瘦素水平为 (15 .1± 7.4) μg/L ,对照组瘦素水平为 (9.1± 4.9) μg/L ,两组比较 ,差异极有显著性 (P <0 .0 0 1)。相关分析显示 ,孕妇血清瘦素水平与其体重 (r =0 .5 2 9)、体重指数 (r =0 .5 5 1)、腹围 (r=0 .5 6 4)、子宫底高度 (r =0 .15 1)、收缩压 (r =0 .134 )、舒张压 (r=0 .2 5 1)均有相关性。妊娠期间 ,血清瘦素水平虽然逐渐上升 ,但直到孕 30周 ,统计学上尚无明显差异。结论　监测孕妇瘦素水平变化 ,对妊娠并发症 (如妊娠高血压综合征 )的临床观察可能有一定的意义

Serum Leptin Levels during Pregnancy

OBJECTIVE: To study the serum leptin levels in Chinese pregnant women, and to discuss the relationship between leptin level and pregnancy. METHODS: Serum leptin concentrations of 251 pregnant women (13.6 to 30.9 gestational weeks) were measured with radioimmunoassay, and 35 age and body mass index (BMI) matched non-pregnant women were selected as control. Serum leptin concentrations were compared between pregnant and control women, correlations between leptin concentrations and gestational age, weight, BMI, blood pressure and other parameters were analyzed. RESULTS: In these pregnant women, aged (28.5 +/- 3.9) years, BMI (23.6 +/- 2.8) kg/m2, serum leptin concentrations were (15.1 +/- 7.4) micrograms/L; while in control women, aged (27.4 +/- 3.8) years, BMI (22.6 +/- 2.5) kg/m2, serum leptin concentrations were (9.1 +/- 4.9) micrograms/L. The mean age and BMI are comparable between 2 groups. Serum leptin concentrations in pregnant women were much higher than those in control women (P < 0.001). Within the pregnant women, serum leptin concentrations were significantly correlated to body weight(r = 0.529), BMI (r = 0.551,), waist circumference (r = 0.564), height of uterus bottom (r = 0.151), systolic blood pressure (r = 0.134) and diastolic blood pressure (r = 0.251). During pregnancy, serum leptin concentrations rose along with the gestational age, although no statistical difference was revealed up to 30th gestational week. CONCLUSIONS: Leptin is a hormone intimately related to the pregnancy, its concentrations are much higher during pregnancy than those of non-pregnant women with matched age and BMI. Like in non-pregnant women, leptin levels are significantly correlated to body weight and BMI, and also correlated to blood pressure, the correlation between leptin and diastolic blood pressure is more evident, indicating that serum leptin may serve as a marker for detecting and monitoring pregnancy complications.