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| 焦炉工人外周血淋巴细胞凋亡特征分析 | |
| 引用本文： | 胡志鹏,张红明,李卫星,张晶,宋秋坤,王保平,李治玉,郑金平. 焦炉工人外周血淋巴细胞凋亡特征分析[J]. 环境与职业医学, 2011, 28(3): 152-155 |
| 作者姓名： | 胡志鹏 张红明 李卫星 张晶 宋秋坤 王保平 李治玉 郑金平 |
| 作者单位： | 胡志鹏,李卫星,张晶,宋秋坤,郑金平,HU Zhi-peng,LI Wei-xing,ZHANG Jing,SONG Qiu-kun,ZHENG Jin-ping(山西医科大学公共卫生学院毒理学教研室,山西,太原030001);张红明,王保平,李治玉,ZHANG Hong-ming,WANG Bao-ping,LI Zhi-yu(山西焦化集团有限公司,山西,洪洞,041601) |
| 基金项目： | 国家自然科学基金，山西省自然科学基金，山西医科大学科技创新基金 |
| 摘 要： | [目的]研究焦炉工人外周血淋巴细胞凋亡特征及其影响因素,为加强焦炉工的健康防护提供指导依据。[方法]收集343名焦炉工人班后尿,高效液相色谱法测定尿1-羟基芘（1-OHP）浓度,按尿1-OHP浓度将研究对象分为低、中、高暴露组。分光光度法测定血浆乳酸脱氢酶（LDH）活性和丙二醛（MDA）含量,流式细胞仪测定淋巴细胞凋亡率。[结果]以低暴露组淋巴细胞凋亡率95%上限值（7.90%）为界值判断淋巴细胞凋亡阳性,结果显示,低、中、高暴露组淋巴细胞凋亡阳性率随剂量升高而升高（趋势检验P〈0.01）。经多因素Logistic回归分析,中暴露组、高暴露组和夜班是淋巴细胞凋亡阳性的主要危险因素（OR分别为3.42、8.58和5.05,P值均小于0.05）。相关分析结果显示,淋巴细胞凋亡率与尿1-OHP含量呈正相关（r=0.113,P〈0.05）。[结论]焦炉逸散物暴露可导致部分焦炉工人淋巴细胞凋亡率升高,且与尿1-OHP水平有关。夜班是主要影响因素。 |
| 关 键 词： | 焦炉工人 淋巴细胞 细胞凋亡 影响因素 |
Characteristics of Peripheral Blood Lymphocytes Apoptosis in Coke-oven Workers |
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| HU Zhi-peng,ZHANG Hong-ming,LI Wei-xing,ZHANG Jing,SONG Qiu-kun,WANG Bao-ping,LI Zhi-yu,ZHENG Jin-ping. Characteristics of Peripheral Blood Lymphocytes Apoptosis in Coke-oven Workers[J]. Journal of Environmental & Occupational Medicine, 2011, 28(3): 152-155 | |
| Authors: | HU Zhi-peng ZHANG Hong-ming LI Wei-xing ZHANG Jing SONG Qiu-kun WANG Bao-ping LI Zhi-yu ZHENG Jin-ping |
| Affiliation: | HU Zhi-peng1,ZHANG Hong-ming2,LI Wei-xing1,ZHANG Jing1,SONG Qiu-kun1,WANG Bao-ping2,LI Zhi-yu2,ZHENG Jin-ping1(1.Department of Toxicology,School of Public Health,Shanxi Medical University,Taiyuan,Shanxi 030001,China,2.Shanxi Coking Group Co.,Ltd.,Hongtong,Shanxi 041601,China) |
| Abstract: | [Objective] To investigate the characteristics of lymphocytes apoptosis in peripheral blood of coke-oven workers and its influential factors.[Methods] In this study,a total of 343 coke-oven workers were included.1-Hydroxypyrene(1-OHP)in worker's post-shift urine sample was determined by high performance liquid chromatography.Subjects were divided into low,medium or high exposure group according to the 1-OHP concentration.Lactic dehydrogenase(LDH)activity and malondialchehyche(MDA)concentration in plasma wer... |
| Keywords: | coke-oven workers lymphocyte apoptosis influential factors |
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