| 新生儿黄疸的遗传因素 |
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| 引用本文： | 杨立业,王朋朋. 新生儿黄疸的遗传因素[J]. 分子诊断与治疗杂志, 2013, 0(3): 206-210 |
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| 作者姓名： | 杨立业 王朋朋 |
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| 作者单位： | 1. 广东省潮州市中心医院检验实验中心,广东,潮州521021
2. 广东省潮州市中心医院儿科,广东,潮州521021 |
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| 摘 要： | 新生儿黄疸是全球儿科医生共同面对的难题，遗传因素在新生儿黄疸的发病中起重要作用。目前的研究认为，与新生儿黄疸发生有关的因素主要有G6PD、尿苷二磷酸葡萄糖醛酸转移酶1A1、编码有机阴离子转运体（OATP）的基因SLC0181和SLC0183，以及血红素加氧酶1和胆绿素还原酶A。
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| 关 键 词： | 新生儿 病理性黄疸 新生儿高胆红素血症 溶血 |
The genetic factors of neonatal jaundice |
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| YANG Liye,WANG Pengpeng. The genetic factors of neonatal jaundice[J]. Journal of Molecular Diagnosis and Therapy, 2013, 0(3): 206-210 |
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| Authors: | YANG Liye WANG Pengpeng |
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| Affiliation: | 1.Laboratory Medical Center, Chaozhou Central Hospital, Guangdong, Chaozhou 521021, China; 2.Department of Pediatrics, Chaozhou Central Hospital, Guangdong, Chaozhou 521021, China) |
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| Abstract: | Neonatal jaundice is the problem that the world＇s pediatrician to face together. The genetic factors play an important role in the pathogenesis of neonatal jaundice. The current studies suggested that the major factors associated with neonatal jaundice including glucose-6-phosphate dehydrogenase deficiency （G6PD）, uridine diphosphate glucuronic transferase 1A1 （UGT1A1）, the SLCO1B1 and SLCO1B3 gene that encode the organic anion-transporting polypeptide （OATP）, heme oxygenase 1 and biliverdin reductase A. |
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| Keywords: | Newborn Pathological jaundice Neonatal hyperbilirubinemia Hemolysis |
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