Synthesis and antioxidant activity of 1-(4-fluorophenyl)-1-alkyl-2-phenyl-3-morpholinopropan-1-ol hydrochlorides |
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| Authors: | A. U. Isakhanyan G. A. Gevorgyan N. Z. Akopyan M. H. Malakyan L. A. Vardevanyan S. A. Badjinyan G. A. Panosyan |
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| Affiliation: | (1) Mndjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, 0014, Armenia;(2) Scientific Center of Radiation Medicine and Burns, Ministry of Public Health of Armenia, Yerevan, 0048, Armenia;(3) Molecular Structure Research Center, National Academy of Sciences of Armenia, Yerevan, 0014, Armenia |
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| Abstract: | ![]()
Reactions of 4-fluorophenyl-β-morpholinopropiophenones with various Grignard reagents in anhydrous ether produced new tertiary aminoalcohols, 1-(4-fluorophenyl)-1-alkyl-2-phenyl-3-morpholinopropan-1-ols, that can be regarded as trihexyphenidyl (cyclodol) analogs. The antioxidant properties of the synthesized compounds were studied using a photochemiluminescence analytical method. It is established that the synthesized compounds exhibit antioxidant activity, the intensity of which depends on the length of the alkyl chain in the para-position of the benzene ring. |
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