菊花、党参二氧化硫含量测定方法比较与分析

目的:确定利用《中国药典》收录方法测定中药二氧化硫操作易出问题的环节,提示测定操作的注意事项,以便使测定操作更加完善、结果更加准确。同时了解菊花、党参样品二氧化硫污染状况。方法:以党参和菊花样本为研究材料,利用《中国药典》方法和《欧洲药典》方法测定其中二氧化硫的含量,对比测定结果和测定过程,分析产生误差的原因。结果:按《中国药典》方法测定的结果,20个党参样品中超过400mg·kg-1的样本有6个,10个菊花样本均在30mg·kg-1以下,都符合150mg·kg-1的标准。结论:实验环节中滴定的起点、二氧化硫吸收过程、滴定终点的判断都会影响结果,应严格控制。菊花的二氧化硫污染较少,党参污染相对严重,需要加大监管治理力度,给市场提供合格的药材,保证用药安全。

Comparison and Analysis of Methods for Determining Sulfur Dioxide in Chrysanthemi Flos and Codonopxis Radix

Objective: To find the steps where problems may occur easily by the method and point out the notes when determining sulfur dioxide in traditional Chinese medicine, thus the operations can be improved and the results can be more accurate. Understanding SO₂ pollution of medicinal Codonopsis Radix and Codonopsis Radix samples. Method: The methods for determining sulfur dioxide according to Chinese Pharmacopoeia and European Pharmacopoeia were used to determine sulfur dioxide in Chrysanthemi Flos and Codonopsis Radix. The results and operations were compared, and then the causes of error were analysed. Result: According to the results of Chinese Pharmacopoeia method, 6 of 20 samples of Codonopsis Radix over 400 mg · kg^-1, 10 Chrysanthemi Flos samples were under 30 mg · kg^-1, it is up to the grade of 150 mg · kg^-1. Conclusion: The experimental results show that the starting point of titration, sulfur dioxide absorption process, the titration end point judgment will affect the results, should be strictly controlled. Chrysanthemi Flos of sulfur dioxide pollution less, Codonopsis Radix pollution is relatively serious, we should strengthen supervision and management the market to provide qualified drugs to ensure drug safety.