吸烟对短暂性脑缺血发作患者血浆组织因子水平的影响

目的观察短暂性脑缺血发作(TIA)吸烟者血浆组织因子(TF)水平的变化及其临床意义。方法回顾分析29例TIA吸烟者(TIA吸烟组)和29例TIA不吸烟者(TIA不吸烟组)血浆TF水平变化,并选用24例健康吸烟者(健康吸烟组)和24例健康不吸烟者(健康不吸烟组)作为对照,同时从TIA吸烟者和健康吸烟者中选出12例戒烟者作为戒烟组。血浆TF水平检测采用双抗体夹心酶联免疫分析法。结果TIA吸烟组血浆TF水平明显高于TIA不吸烟组(P<0.05)和健康不吸烟组(P<0.01),健康吸烟组血浆TF水平明显高于健康不吸烟组(P<0.05);血浆TF水平随着吸烟程度的加重而增高,吸烟者血浆基础TF水平与吸烟指数呈正相关(r=0.450,P<0.001),吸烟2h后血浆基础TF水平明显升高,而戒烟2周后血浆基础TF水平恢复至近正常水平。结论长期吸烟致TIA患者血浆TF水平增高可能在脑血栓形成中发挥重要作用。

Effect of cigarette smoking on the level of plasma tissue factor in transient ischemic attack patients

Objective To explore the effect of cigarette smoking on the level of plasma tissue factor(TF) in patients with transient ischemic attack(TIA) and its clinical significance. Methods Twenty-nine smokers with TIA and 29 non-smokers with TIA were analyzed retrospectively.Twenty-four healthy smokers and 24 healthy non-smokers served as controls. Twelve ex-smokers served as ex-smoker group simultaneously.The level of TF was detected with two-layer antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The level of plasma TF in smokers with TIA was higher than that in non-smokers with TIA(P<0.05)and was much higher than that in healthy non-smokers(P<0.01).The level in healthy smokers was higher than that in healthy non-smokers(P<0.05).It increased with smoking level and was positively correlated with smoking index (r=0.450, P<0.05). The basal level of TF increased 2 hours after smoking 1 cigarette and returned to normal level 2 weeks after ceasing smoking. Conclusion The level of plasma TF increased in smokers with TIA, and it may play an important role in cerebral thrombosis.