| 在多发性骨髓瘤中bcl-1基因重排、细胞周期D_1蛋白高表达及其临床意义 |
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| 引用本文： | 唐泽海!武汉,游泳!武汉,刘新月!武汉,李惠玉!武汉,向建平!武汉,邹萍!武汉.在多发性骨髓瘤中bcl-1基因重排、细胞周期D_1蛋白高表达及其临床意义[J].华中医学杂志,1999(5). |
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| 作者姓名： | 唐泽海!武汉 游泳!武汉 刘新月!武汉 李惠玉!武汉 向建平!武汉 邹萍!武汉 |
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| 作者单位： | 同济医科大学附属协和医院血液科 |
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| 摘 要： | 21例多发性骨髓瘤患者的外周血和骨髓的单个核细胞,同时用免疫组织化学和两步法半筑巢式多聚酶链反应(PCR)技术进行分析,检出5例(24%)细胞周期D_1蛋白高表达,4例(19%)bcl-1基因重排.该4例bcl-1基因重排的患者都高表达细胞周期D_1蛋白.5例细胞周期D_1蛋白高表达的患者都具有较晚的临床分期、骨髓中瘤细胞比率较高、化疗效果差等特点.
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| 关 键 词： | 多发性骨髓瘤 bcl-1基因重排 细胞周期D_1蛋白 |
Bcl-1 Rearrangement and Highcyclin D_1 Protein Expression in Multiple Myeloma and Their Clinical Implication |
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| Tang Zehai,You Yong,Liu Xinyue et al.Bcl-1 Rearrangement and Highcyclin D_1 Protein Expression in Multiple Myeloma and Their Clinical Implication[J].Central China Medical Journal,1999(5). |
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| Authors: | Tang Zehai You Yong Liu Xinyue |
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| Institution: | Tang Zehai,You Yong,Liu Xinyue et al. Department of Hematology,Xiehe Hospial,Tongji Medical University,Wuhan 430022 |
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| Abstract: | The rearrangement of bcl-1gene and the expression of cyclin D] protein in peripheral blood and marrow mononuclear cells in 21 multiple myeloma (MM) patients were simultaneously analyzed by using immunohistochemistry method and hemi-nested polymerase chain reaction (PCR). 4/21(19%) MM patients displayed bcl-1 rearrangement by PCR and 5/21 (24%)MM patients showed cyclin D1 overexpression by immunohistochemistry method. All 4 cases of bcl-1 rearrangement had overexpression of cyclin D1 protein, bcl-1 rearrangement and(or)cyclin D1 protein overexpression was a poor prognostic marker for MM patients. Five cases of cyclin D1 protein overexpression were characterized by advanced clinical stage .a highly disseminated tumor,and the refractoriness to standard therapy. |
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| Keywords: | multiple myeloma rearrangement of bcl-1 cyclin D1 protein |
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