| HSP70与FasL在子宫内膜异位症中的表达 |
| |
| 引用本文： | 王滨,郑维国,辛晓燕,王德堂,郭会玲,于月成. HSP70与FasL在子宫内膜异位症中的表达[J]. 现代妇产科进展, 2003, 12(4): 264-266 |
| |
| 作者姓名： | 王滨 郑维国 辛晓燕 王德堂 郭会玲 于月成 |
| |
| 作者单位： | 第四军医大学西京医院妇产科,西安,710032 |
| |
| 摘 要： | 目的 :探讨热休克蛋白 70 (HSP70 )和Fas配体 (FasL)在子宫内膜异位症(EM)发病中的作用。方法 :采用免疫组化链霉菌抗生物素蛋白 -过氧化物酶染色法 (S P法 )检测子宫内膜异位症 5 6例的异位内膜与在位内膜 (30例 )中HSP70和FasL蛋白的表达 ,并以正常子宫内膜为对照 (2 5例 )。结果 :异位内膜组织中HSP70与FasL均呈高表达 ,与正常内膜组差异有高度显著性 (P <0 .0 1) ,而且二者失去在正常内膜组织中表达的周期性变化。但在卵巢子宫内膜异位症 (OEM)与子宫腺肌症 (AM)的表达差异无显著性 (P>0 .0 5 )。结论 :异位内膜组织中HSP70和FasL蛋白均过度表达 ,可能在EM的发病中起重要作用
|
| 关 键 词： | 热休克蛋白质70 Fas配体 子宫内膜异位症 凋亡细胞 免疫赦免 |
| 文章编号： | 1004-7379(2003)04-0264-03 |
| 修稿时间： | 2003-01-07 |
Expression of HSP70 and FasL in eutopic and ectopic endometrium in endometriosis and adenomyosis |
| |
| Wang Bin,Zheng Weiguo,Xin Xiaoyan,et al.. Expression of HSP70 and FasL in eutopic and ectopic endometrium in endometriosis and adenomyosis[J]. Current Advances In Obstetrics and Gynecology, 2003, 12(4): 264-266 |
| |
| Authors: | Wang Bin Zheng Weiguo Xin Xiaoyan et al. |
| |
| Affiliation: | Wang Bin,Zheng Weiguo,Xin Xiaoyan,et al.Department of Obstetrics and Gynecology,Xijing Hospital of Fourth Military Medical University,Xi'an 710032 |
| |
| Abstract: | Objective:To investigate the role of HSP70 and FasL in the pathogenesis of endometriosis (EM) and adenomyosis.Method:Immunohistochemical S P method was employed to detect the expression of HSP70 and FasL in the ectopic tissues and eutopic endometrium of patients with EM (56 cases) and the normal controls (25 cases).Results:The expression levels of HSP70 and FasL in ectopic and eutopic endometrium in EM were both higher than those in controls (both P<0.01) and were irrespective of the phases of menstrual cycle. But there has no difference between their expressions in EM and adenomyosis patients.Conclusions:HSP70 and FasL are abnormally overexpressed in endometriosis and adenomyosis,and may play an important role in the pathophysiology of these diseases. |
| |
| Keywords: | Heat shock proteins 70 Fas ligard Endometriosis Apoptosis Immune privilege |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
