| 5-氟尿嘧啶筛选残存结肠癌细胞的生物学特点及其与CD133表达的关系 |
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| 引用本文： | 张军荣,穆继英,杨爱军,尚立娜,牛茜.5-氟尿嘧啶筛选残存结肠癌细胞的生物学特点及其与CD133表达的关系[J].第三军医大学学报,2011,33(1):18-23. |
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| 作者姓名： | 张军荣 穆继英 杨爱军 尚立娜 牛茜 |
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| 作者单位： | 甘肃省卫生学校基础教研室;兰州大学人体解剖与组织胚胎学研究所;兰州大学病理学研究所; |
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| 基金项目： | 甘肃省自然科学研究基金(096RJZA053)~~ |
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| 摘 要： | 目的 研究5-氟尿嘧啶(5-Fluorouracil,5-FU)筛选残存结肠癌细胞(drug surviving cells,DSCs)是否具有癌症干细胞(cancer stem cells,CSCs)属性及其增殖过程中免疫表型的改变.方法 应用5-FU对体外培养的结肠癌细胞株SW480进行处理,收集残存DSCs,检测...
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| 关 键 词： | 5-氟尿嘧啶 结肠癌 CD133 癌症干细胞 |
Biological characteristics of colon carcinoma cells surviving 5-fluorouracil treatment and their relationship with CD133 expression |
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| Zhang Junrong,Mu Jiying,Yang Aijun,Shang Lina,Niu Qian.Biological characteristics of colon carcinoma cells surviving 5-fluorouracil treatment and their relationship with CD133 expression[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(1):18-23. |
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| Authors: | Zhang Junrong Mu Jiying Yang Aijun Shang Lina Niu Qian |
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| Institution: | Zhang Junrong1,Mu Jiying2,Yang Aijun3,Shang Lina3,Niu Qian3(1Department of Basic Medicine,Gansu Provincial Health School,Lanzhou,Gansu Province,730000,2Institute of Human Anatomy,Histology and Embryology,3Institute of Pathology,Basic Medical College of Lanzhou University,China) |
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| Abstract: | Objective To collect drug surviving cells(DSCs) of colon carcinoma cell line SW480 surviving 5-fluorouracil(5-FU) in vitro treatment,to study the characteristics of cancer stem cells(CSCs) in DSCs,and to investigate the immunophenotype changes in the proliferation process of DSCs.Methods Colon carcinoma cell line SW480 was treated with 5-FU in vitro,and then DSCs were collected.The cell cycle,cloning efficiency,positive rate of CD133,and tumorigenesis efficiency in SCID mice of DSCs were detected.DSCs were ... |
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| Keywords: | 5-fluorouracil colon carcinoma CD133 cancer stem cell |
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