2型糖尿病大血管病变与血清糖基化低密度脂蛋白及循环免疫复合物的关系

目的：观察血清糖基化低密度脂蛋白及循环免疫复合物的变化与２ 型糖尿病大血管病变的关系。方法：对 ５８ 例２ 型糖尿病２ 型糖尿病病人（３０ 例有大血管病变，２８ 例无血管病变）及４６ 例正常人，采用氯化硝基四唑氮蓝还原比色法测定了血清糖化低密度脂蛋白（糖化 Ｌ Ｄ Ｌ），采用聚乙二醇沉淀法测定了循环免疫复合物（ Ｃ Ｉ Ｃ）。结果：２ 型糖尿病并发大血管病变组与无血管病变组之间比较，糖化 Ｌ Ｄ Ｌ、 Ｃ Ｉ Ｃ水平明显升高。２ 型糖尿病病人血清糖化 Ｌ Ｄ Ｌ水平与 Ｃ Ｉ Ｃ的水平呈极显著正相关。结论：２ 型糖尿病病人血清糖化 Ｌ Ｄ Ｌ及 Ｃ Ｉ Ｃ的增高与其大血管病变密切相关，糖化 Ｌ Ｄ Ｌ及 Ｃ Ｉ Ｃ的代谢异常对于 ２ 型糖尿病大血管病变的发生有协同作用。

Relationship Between Macroangiopathy and Serum Glycosylated Low Density Lipoprotein as well as Circulating Immune Complexes in NIDDM

Objective: This paper was designed to observe the relationship between macroangiopathy and serum glycosylated low density lipoprotein (GlyLDL) as well as circulating immune complexes (CIC) in patients with tpye 2 diabetes mellitus. Methods: We measured the levels of plasma GlyLDL with nitroblue tetrazolium reduction technique and CIC with polyethylene glycol precipitation method. 58 patients with type 2 diabetes mellitus and 46 healthy controls were selected. Among the patients 30 were complicated with macroangiopathy and 28 were not. Results: The levels of plasma GlyLDL and CIC from type 2 diabetes mellitus subjects in those with macroangiopathy complication were significantly higher than in those without complication. Conclusions: Remarkably positive correlation was present between the level of plasma GlyLDL and that of plasma CIC in patients with type 2 diabetes mellitus. The elevated levels of GlyLDL and CIC were closely related to the incidence of macroangiopathy in type 2 diabetes mellitus. Abnormal GlyLDL and CIC acted synergetically on the development of macroangiopathy.