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| P16、Rb、C—myc基因在肾癌中的表达及其与细胞凋亡的关系 | |
| 引用本文： | 周鹤同,郭震华,苏长青. P16、Rb、C—myc基因在肾癌中的表达及其与细胞凋亡的关系[J]. 现代泌尿外科杂志, 2001, 6(1): 16-18 |
| 作者姓名： | 周鹤同 郭震华 苏长青 |
| 作者单位： | 1. 210048,南京江北人民医院 2. 苏州医学院第一附属医院泌尿外科 3. 中国人民解放军肿瘤研究中心 |
| 摘 要： | 目的探讨P16、Rb、C-myc基因在肾癌中的表达以及肾癌组织中细胞凋亡的发生，了解两之间的相互关系。方法采用免疫组织化学法检测肾癌组织中的P16、Rb、C—myc基因的表达情况，同时用TUNEL法观察肾癌中细胞凋亡现象。结果在肾癌中，P16总阳性率为61．3％，Rb总阳性率为64．5％，C—myc总阳性率为48．4％，它们的阳性表达与细胞凋亡有相关性。结论肾癌中P16、Rb、C—myc基因促进肾癌细胞凋亡的发生，在机体抗肿瘤机制中起积极作用。 |
| 关 键 词： | 肾癌组织 C—myc基因 细胞凋亡 阳性表达 阳性率 抗肿瘤机制 肾癌细胞 C-myc基因 免疫组织化学法 积极作用 |
| 修稿时间： | 2000-09-16 |
Expressions of Pi Kh. C -myc gene in Renal Cell Carcinoma and its relationship to Apoptosis |
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| ZHOU Hetong,GUO Zhenhua,SU Changqing. Expressions of Pi Kh. C -myc gene in Renal Cell Carcinoma and its relationship to Apoptosis[J]. Journal of MOdern Urology, 2001, 6(1): 16-18 | |
| Authors: | ZHOU Hetong GUO Zhenhua SU Changqing |
| Affiliation: | ZHOU Hetong GUO Zhenhua,SU Changqing,NanJingJiangbei,Hospital,210048 |
| Abstract: | Objective Fe investigate the relationship between apcptosis and gene expressions in renal cell carcinoma. Methods Immunohistechemistry was applied to detect the gene expressions of P16,Rb,C- myc, wheraes the events of apoptosis in renal cell carcinoma were observed by TUNEI, technique. Results In renal cell carcinoma.the total positive rate of P16 ,Rb and C - myc were 61.5% .64.5% and 4. 4% respectively , They were correlated to the apoptesis of cancer cells. Conclusions The genes of P16 ,Rb and C - myc. impel the apop-tosis in renal coll carcinoma and play an active role in the mechanism of antincoplasties. |
| Keywords: | Renal neoplasm P16 gene Kb gene C - myc gene Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |