Molecular and clinicopathological analysis of dermatofibrosarcoma protuberans |
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| Authors: | Kassandra Walluks,Yuan Chen,Cornelius Woelfel,Linlin Yang,Tiantian Cui,Claudia Seliger,Christiane Geier,Thomas Knö sel,Sven Hauke,Iver Petersen |
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| Affiliation: | 1. Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University Jena, Ziegelmühlenweg 1, 07743 Jena, Germany;2. ZytoVision GmbH, Fischkai 1, D-27572 Bremerhaven, Germany |
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| Abstract: | ![]()
Dermatofibrosarcoma protuberans (DFSP) is a dermal and subcutaneous tumor of intermediate malignancy. The most remarkable cytogenetic feature of DFSP is the chromosomal translocation t(17;22)(q22;q13), causing a fusion of the platelet-derived growth factor beta chain (PDGFB) gene at 22q13, and the collagen type 1 alpha 1 (COL1A1) at 17q22. The aim of the study was to analyze the molecular characteristic of DFSP in conjunction with histopathological and clinical features. |
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| Keywords: | Dermatofibrosarcoma protuberans Multiplex RT-PCR FISH Amplification |
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