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| 5-羟色胺转运体基因多态性与肠易激综合征 | |
| 引用本文： | 代子艳,王巧民. 5-羟色胺转运体基因多态性与肠易激综合征[J]. 国际消化病杂志, 2008, 28(5) |
| 作者姓名： | 代子艳 王巧民 |
| 作者单位： | 安徽医科大学附属省立医院消化内科,230001 |
| 摘 要： | 肠易激综合征(IBS)是临床最常见的功能性肠病,其病因及发病机制还不完全清楚。5-羟色胺(5-HT)是参与调节胃肠道运动和分泌功能的重要神经递质,在IBS的发病中有重要意义。5-羟色胺转运体(SERT或5-HTT)蛋白再摄取神经突触间隙的5-HT,对其起灭活作用。大量研究表明,SERT基因多态性与IBS各型间可能存在联系。 |
| 关 键 词： | 5-羟色胺转运体 肠易激综合征 基因多态性 5-羟色胺 |
Serotonin transporter gene polymorphism and irritable bowel syndrome |
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| DAI Zi-yan,WANG Qiao-min. Serotonin transporter gene polymorphism and irritable bowel syndrome[J]. International Journal of Digestive Disease, 2008, 28(5) | |
| Authors: | DAI Zi-yan WANG Qiao-min |
| Abstract: | IBS is the most common functional gastrointestinal(GI) disease,which etiopathogenisis is not completely understood. As a key neurotransmitter modulating GI motility and secretion,serotonin plays critical an role in the complex pathophysiology of the IBS. SERT can reuptake 5-HT from nerve synaptic space and terminate its actions. Many researches suggest that the possible relationship exists between serotonin transporter gene polymorphism and the subtypes of IBS. |
| Keywords: | Serotonin reuptake transporter Irritable bowel syndrome Gene polymorphism Serotonin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |